INT258063

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 22 55.36 Quite High
lidocaine 2 31.76 Quite Low
Pain 3 21.12 Low Low
antagonist 74 5.00 Very Low Very Low Very Low
Bioavailability 24 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Angina 14 5.00 Very Low Very Low Very Low
gABA 10 5.00 Very Low Very Low Very Low
headache 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 22 82.08 Quite High
Colon Cancer 9 78.96 Quite High
Systemic Lupus Erythematosus 12 73.12 Quite High
Syndrome 8 62.04 Quite High
Myelodysplastic Syndromes 58 61.04 Quite High
Cancer 311 58.60 Quite High
Myeloid Leukemia 46 54.20 Quite High
Vomiting 32 48.52 Quite Low
Heart Rate Under Development 36 45.20 Quite Low
Arrhythmia Under Development 4 39.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However it was later found that the ability of these drugs at low doses to inhibit DNMT1 and cause DNA hypomethylation, thereby restoring normal function to genes that have a key role in the control of cellular differentiation and proliferation [52-54].
Negative_regulation (inhibit) of DNMT1
1) Confidence 0.28 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.17 Pain Relevance 0
At micromolar concentrations, procainamide was found as a partial competitive DNMT1 inhibitor, reducing the enzyme's affinity for its two substrates: hemimethylated DNA, and S-adenosyl-l-methionine.
Spec (partial) Negative_regulation (inhibitor) of DNMT1
2) Confidence 0.25 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.60 Pain Relevance 0
By doing this, procainamide significantly decreased DNMT1 processivity on hemimethylated DNA.
Negative_regulation (decreased) of DNMT1
3) Confidence 0.22 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.47 Pain Relevance 0.11
Effective oral administration of DNMT inhibitors requires either high doses of drug or co-administration of the cytidine deaminase inhibitor tetrahydouridine (THU; 8, 9).
Negative_regulation (inhibitors) of DNMT
4) Confidence 0.08 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.12 Pain Relevance 0

General Comments

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