INT258077

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 7 62.24 Quite High
headache 5 58.40 Quite High
Bioavailability 15 44.00 Quite Low
antagonist 37 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 178 96.52 Very High Very High Very High
Toxicity 22 86.00 High High
Solid Tumor 10 80.08 Quite High
Syndrome 4 65.88 Quite High
Systemic Lupus Erythematosus 6 65.32 Quite High
Cv General 3 Under Development 7 62.24 Quite High
Dizziness 6 61.40 Quite High
Heart Rate Under Development 18 60.96 Quite High
Hypotension 7 59.92 Quite High
Increased Venous Pressure Under Development 6 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrariwise, other authors have reported that hydralazine decreases DNA methyltransferase 1 and 3a expression in a similar manner to PD98059, a Mitogen-activated protein kinase kinase (MEK) inhibitor, this suggesting that hydralazine does not directly inhibit DNA methyltransferase enzymatic activity [173].
Negative_regulation (decreases) of Gene_expression (expression) of DNA methyltransferase 1
1) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.91 Pain Relevance 0.12
This agent was able to inhibit DNMT1 expression without effecting DNMT3, causing demethylation with reexpression of silenced genes in cancer cell lines and tumor growth inhibition in mouse models.
Negative_regulation (inhibit) of Gene_expression (expression) of DNMT1 associated with cancer
2) Confidence 0.28 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.36 Pain Relevance 0

General Comments

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