INT258081

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.57
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 4
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 24 100.00 Very High Very High Very High
Neurotransmitter 11 99.38 Very High Very High Very High
pregabalin 63 97.56 Very High Very High Very High
Antinociceptive 1 91.36 High High
anticonvulsant 6 90.52 High High
Bioavailability 22 88.16 High High
Fibrositis 147 78.60 Quite High
substance P 1 77.44 Quite High
Calcitonin gene-related peptide 1 76.40 Quite High
Glutamate 1 73.44 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 22 96.36 Very High Very High Very High
Epilepsy 20 95.16 Very High Very High Very High
Convulsion 14 91.20 High High
Anxiety Disorder 19 89.88 High High
Fibromyalgia 147 78.60 Quite High
Depression 54 66.80 Quite High
Absence Epilepsy 4 65.44 Quite High
Partial Seizures 2 60.56 Quite High
Juvenile Myoclonic Epilepsy 2 58.72 Quite High
Breast Cancer 44 57.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the human brain, valproic acid affects neurotransmitter GABA function by potentiating GABA inhibitory activity by several means, including inhibition of GABA degradation, increased GABA synthesis, and decreased GABA turnover.
Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
1) Confidence 0.10 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.39 Pain Relevance 0.34
It also has no effect on GABA uptake, degradation, or cerebral concentrations.25 It is currently thought that pregabalin’s effects are instead mediated by its aff inity for the alpha-2-delta-1 subunit protein of VGCCs.
Protein_catabolism (degradation) of GABA associated with pregabalin and gaba
2) Confidence 0.07 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 0.72 Pain Relevance 1.35
In the human brain, valproic acid affects neurotransmitter GABA function by potentiating GABA inhibitory activity by several means, including inhibition of GABA degradation, increased GABA synthesis, and decreased GABA turnover.
Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
3) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.40 Pain Relevance 0.34
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
4) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.50 Pain Relevance 0.36
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
5) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.57 Pain Relevance 0.47

General Comments

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