INT258086

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2, IGFBP3) extracellular region (CSF2, IGFBP3) nucleus (IGFBP3)
CSF2 (Homo sapiens)
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 6 49.64 Quite Low
Neurotransmitter 2 18.56 Low Low
Locus ceruleus 16 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 138 99.62 Very High Very High Very High
Neuroblastoma 4 96.64 Very High Very High Very High
Targeted Disruption 86 88.80 High High
Disease 8 65.68 Quite High
Death 20 30.12 Quite Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An IGFBP3 polymorphism known to increase IGFBP3 serum levels is associated with reduced CSF hypocretin levels
CSF Binding (associated) of IGFBP3
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.48 Pain Relevance 0
Although we found no IGFBP3 autoantibodies nor a genetic association with IGFBP3 polymorphisms in human narcolepsy, we found that an IGFBP3 polymorphism known to increase serum IGFBP3 levels was associated with lower CSF hypocretin-1 in normal individuals.


CSF Binding (associated) of IGFBP3 associated with sleep disorders
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.70 Pain Relevance 0

General Comments

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