INT258092

Context Info Confidence 0.44 First Reported 2008 Last Reported 2009 Negated 0 Speculated 2 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.60 Pain Relevance 0.29

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)

Anatomy Link Frequency hypothalamus 4 Hcrt (Mus musculus)

Pain Link Frequency Relevance Heat Locus ceruleus 33 97.32 Thalamus 5 96.64 cerebral cortex 3 95.92 Neuropeptide 9 87.16 medulla 15 74.20 positron emission tomography 3 61.68 depression 4 58.92 gABA 23 18.32 nMDA receptor 2 8.00 adenocard 15 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 214 98.94 Hypersomnia 29 94.52 Targeted Disruption 102 89.60 Gliosis 3 88.48 Neurodegenerative Disease 2 81.84 Cognitive Disorder 8 73.60 Fatigue 1 71.64 Apnoea 12 63.36 Depression 4 58.92 Sleep Apnea Syndromes 1 58.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As noted above, individuals with this condition have marked neuronal loss (85% to 95%) in the hypothalamic regions responsible for producing orexin/hypocretin, including the dorsal and lateral hypothalamus, as well as in the locus coeruleus, thalamus, and the cerebral cortex [86,113].

Regulation (responsible) of Gene_expression (producing) of hypocretin in hypothalamus associated with locus ceruleus, thalamus and cerebral cortex

1) Confidence 0.44 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701283 Disease Relevance 1.48 Pain Relevance 0.21

As hypocretin release is highest at this time of the day (equivalent to the evening in humans), higher IGFBP3 levels may affect hypocretin transmission only at times of highest demand, through the reduction of releasable peptide stores in terminals.

Spec (may) Regulation (affect) of Gene_expression (transmission) of hypocretin

2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.36 Pain Relevance 0.04

In the lesioned mice, the average length of REM sleep bouts did not change at night compared to HCRT-ko mice given saline, but the average length of the non-REM (F1, 26?

Regulation (change) of Gene_expression (saline) of HCRT-ko

3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.18 Pain Relevance 0

We performed gene expression profiling in the hypothalamus to identify novel genes dysregulated in narcolepsy, as these may be the target of autoimmune attack or modulate hypocretin gene expression.

Spec (may) Regulation (modulate) of Gene_expression (expression) of hypocretin in hypothalamus associated with sleep disorders

4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

This test has worked.