INT258092

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.60
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
hypothalamus 4
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 33 97.32 Very High Very High Very High
Thalamus 5 96.64 Very High Very High Very High
cerebral cortex 3 95.92 Very High Very High Very High
Neuropeptide 9 87.16 High High
medulla 15 74.20 Quite High
positron emission tomography 3 61.68 Quite High
depression 4 58.92 Quite High
gABA 23 18.32 Low Low
nMDA receptor 2 8.00 Low Low
adenocard 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 214 98.94 Very High Very High Very High
Hypersomnia 29 94.52 High High
Targeted Disruption 102 89.60 High High
Gliosis 3 88.48 High High
Neurodegenerative Disease 2 81.84 Quite High
Cognitive Disorder 8 73.60 Quite High
Fatigue 1 71.64 Quite High
Apnoea 12 63.36 Quite High
Depression 4 58.92 Quite High
Sleep Apnea Syndromes 1 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As noted above, individuals with this condition have marked neuronal loss (85% to 95%) in the hypothalamic regions responsible for producing orexin/hypocretin, including the dorsal and lateral hypothalamus, as well as in the locus coeruleus, thalamus, and the cerebral cortex [86,113].
Regulation (responsible) of Gene_expression (producing) of hypocretin in hypothalamus associated with locus ceruleus, thalamus and cerebral cortex
1) Confidence 0.44 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701283 Disease Relevance 1.48 Pain Relevance 0.21
As hypocretin release is highest at this time of the day (equivalent to the evening in humans), higher IGFBP3 levels may affect hypocretin transmission only at times of highest demand, through the reduction of releasable peptide stores in terminals.
Spec (may) Regulation (affect) of Gene_expression (transmission) of hypocretin
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.36 Pain Relevance 0.04
In the lesioned mice, the average length of REM sleep bouts did not change at night compared to HCRT-ko mice given saline, but the average length of the non-REM (F1, 26?
Regulation (change) of Gene_expression (saline) of HCRT-ko
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.18 Pain Relevance 0
We performed gene expression profiling in the hypothalamus to identify novel genes dysregulated in narcolepsy, as these may be the target of autoimmune attack or modulate hypocretin gene expression.


Spec (may) Regulation (modulate) of Gene_expression (expression) of hypocretin in hypothalamus associated with sleep disorders
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

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