INT258095

Context Info Confidence 0.29 First Reported 2008 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.86 Pain Relevance 0.23

extracellular space (Igfbp3) nucleus (Igfbp3)

Anatomy Link Frequency blood 1 hypothalamus 1 Igfbp3 (Mus musculus)

Pain Link Frequency Relevance Heat Bioavailability 2 99.00 medulla 4 98.04 cytokine 7 64.56 Inflammation 14 64.00 fibrosis 7 59.88 chemokine 1 38.48 nMDA receptor 2 37.88 tolerance 17 22.68 Dynorphin 2 13.32 Locus ceruleus 16 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 87 99.96 Sprains And Strains 10 98.88 Diabetes Mellitus 19 93.40 Emphysema 1 88.16 Hyperglycemia 2 87.56 Congenital Anomalies 3 85.80 Disease 12 79.20 Fibrosis 17 75.56 Asthma 2 72.60 Sleep Disorders 138 70.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The actions of Igf1 depend largely on its binding to extracellular proteins such as Igfbp2 and Igfbp3 [29-31].

Igfbp3 Binding (binding) of

1) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.56 Pain Relevance 0.13

Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.

hmutIGFBP3 Neg (not) Binding (bind) of in hypothalamus associated with medulla

2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.64 Pain Relevance 0.05

To investigate whether IGFBP3 regulates hypocretin cell physiology and sleep in vivo, we studied IGFBP3 knockout mice (mIgfbp3 KO: C57BL/6J strain) [18] and two human IGFBP3 transgenic lines ( CD-1 strain) [19]: a transgenic mouse strain overexpressing human IGFBP3 (hIGFBP3 transgenic), and a transgenic strain overexpressing a mutated form of hIGFBP3 that does not bind IGF (hmutIGFBP3 transgenic) [20].

hmutIGFBP3 Neg (not) Binding (bind) of associated with targeted disruption and sprains and strains

3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.51 Pain Relevance 0

Among IGFBPs, IGFBP-3 is very important since it binds more than 95% of IGF-I in blood circulation.[22]

IGFBP-3 Binding (binds) of in blood

4) Confidence 0.09 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.15 Pain Relevance 0.05

General Comments

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