INT258095

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.86
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
blood 1
hypothalamus 1
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 99.00 Very High Very High Very High
medulla 4 98.04 Very High Very High Very High
cytokine 7 64.56 Quite High
Inflammation 14 64.00 Quite High
fibrosis 7 59.88 Quite High
chemokine 1 38.48 Quite Low
nMDA receptor 2 37.88 Quite Low
tolerance 17 22.68 Low Low
Dynorphin 2 13.32 Low Low
Locus ceruleus 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 87 99.96 Very High Very High Very High
Sprains And Strains 10 98.88 Very High Very High Very High
Diabetes Mellitus 19 93.40 High High
Emphysema 1 88.16 High High
Hyperglycemia 2 87.56 High High
Congenital Anomalies 3 85.80 High High
Disease 12 79.20 Quite High
Fibrosis 17 75.56 Quite High
Asthma 2 72.60 Quite High
Sleep Disorders 138 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The actions of Igf1 depend largely on its binding to extracellular proteins such as Igfbp2 and Igfbp3 [29-31].
Igfbp3 Binding (binding) of
1) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.56 Pain Relevance 0.13
Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.
hmutIGFBP3 Neg (not) Binding (bind) of in hypothalamus associated with medulla
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.64 Pain Relevance 0.05
To investigate whether IGFBP3 regulates hypocretin cell physiology and sleep in vivo, we studied IGFBP3 knockout mice (mIgfbp3 KO: C57BL/6J strain) [18] and two human IGFBP3 transgenic lines ( CD-1 strain) [19]: a transgenic mouse strain overexpressing human IGFBP3 (hIGFBP3 transgenic), and a transgenic strain overexpressing a mutated form of hIGFBP3 that does not bind IGF (hmutIGFBP3 transgenic) [20].
hmutIGFBP3 Neg (not) Binding (bind) of associated with targeted disruption and sprains and strains
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.51 Pain Relevance 0
Among IGFBPs, IGFBP-3 is very important since it binds more than 95% of IGF-I in blood circulation.[22]
IGFBP-3 Binding (binds) of in blood
4) Confidence 0.09 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.15 Pain Relevance 0.05

General Comments

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