INT258096

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.20
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
neural 1
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 4 95.08 Very High Very High Very High
Locus ceruleus 52 78.24 Quite High
amygdala 8 69.88 Quite High
gABA 32 5.00 Very Low Very Low Very Low
Neuropeptide 16 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
medulla 10 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 40 99.90 Very High Very High Very High
Targeted Disruption 202 99.60 Very High Very High Very High
Injury 4 95.72 Very High Very High Very High
Sarcoma 2 89.56 High High
Sleep Disorders 356 89.36 High High
Apoptosis 16 84.40 Quite High
Cancer 12 58.72 Quite High
Neuroblastoma 8 56.08 Quite High
Malignant Neoplastic Disease 4 55.48 Quite High
Sprains And Strains 50 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we demonstrated that the neurotoxin binds to HCRT receptors [6].
HCRT Binding (binds) of
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.34 Pain Relevance 0.07
Fluorescent activated cell sorting (FACS) analysis was used and determined that, indeed, HCRT2-SAP bound to the HCRT receptor but not the substance-P receptor.
HCRT receptor Binding (bound) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.29 Pain Relevance 0.06
IGFBP3 reduces promotor activity of hypocretin in neural cell lines
hypocretin Binding (activity) of in neural
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.48 Pain Relevance 0
Hypocretin cell counts were nonetheless normal in the hIGFBP3 transgenic model (3269±99 in HZ versus3230±140 in WT, n?
Hypocretin Binding (counts) of associated with targeted disruption
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.05 Pain Relevance 0
Hypocretin-1 radioimmunoassay
Hypocretin-1 Binding (radioimmunoassay) of
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0 Pain Relevance 0
To test the hypothesis that excessive IGFBP3 in hypocretin cells contributes to this cell death, we crossed Hcrt-ataxin-3 transgenic mice (animals with targeted cell death 2–4 weeks after birth) with transgenic mice overexpressing human IGFBP3 (hIGFBP3), but found no effects on the speed of hypocretin cell death.
Hcrt Binding (crossed) of associated with targeted disruption and death
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.04 Pain Relevance 0.05

General Comments

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