INT2581

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.05
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
hepatocyte 4
adipocytes 4
liver 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 100.00 Very High Very High Very High
tolerance 3 100.00 Very High Very High Very High
Chronic pancreatitis 3 99.84 Very High Very High Very High
opiate 5 99.52 Very High Very High Very High
addiction 2 98.48 Very High Very High Very High
narcan 2 95.16 Very High Very High Very High
antagonist 1 94.80 High High
Inflammation 1 93.60 High High
Enkephalin 2 93.24 High High
Dynorphin 1 91.96 High High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 3 100.00 Very High Very High Very High
Acidosis 1 100.00 Very High Very High Very High
Pancreatitis 3 99.84 Very High Very High Very High
Obesity 10 99.32 Very High Very High Very High
Morphine Dependence 2 98.84 Very High Very High Very High
Hepatocellular Cancer 3 98.20 Very High Very High Very High
Insulin Resistance 3 97.24 Very High Very High Very High
Acid Base Imbalance 2 96.12 Very High Very High Very High
INFLAMMATION 3 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of acidosis on insulin binding and glucose uptake in isolated rat adipocytes.
Regulation (Effect) of insulin Binding (binding) of in adipocytes associated with acidosis and obesity
1) Confidence 0.61 Published 1993 Journal Tohoku J. Exp. Med. Section Title Doc Link 8248912 Disease Relevance 0.58 Pain Relevance 0.08
CONCLUSIONS: In the Zucker obese rat, peripheral adipose tissue removes as much insulin from the blood as the liver does, in contrast with lean rats, in which the latter is responsible for practically all insulin extraction.


Regulation (responsible) of insulin Binding (extraction) of in liver
2) Confidence 0.45 Published 1996 Journal Int. J. Obes. Relat. Metab. Disord. Section Body Doc Link 8880351 Disease Relevance 0.11 Pain Relevance 0
The effects of various agents on the binding and degradation of 125I-labelled insulin by isolated rat hepatocytes and cultured H4 hepatoma cells were studied.
Regulation (effects) of insulin Binding (binding) of in hepatocytes associated with hepatocellular cancer
3) Confidence 0.45 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.25 Pain Relevance 0.09
Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide.
Regulation (Alterations) of insulin Binding (binding) of in hepatocyte associated with chronic pancreatitis
4) Confidence 0.27 Published 1995 Journal Am. J. Surg. Section Title Doc Link 7817978 Disease Relevance 0.29 Pain Relevance 0.28
Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes.
Regulation (Effect) of insulin Binding (binding) of in adipocytes associated with obesity, tolerance, impaired glucose tolerance and morphine
5) Confidence 0.25 Published 2001 Journal Endocr. Res. Section Title Doc Link 11428713 Disease Relevance 0.48 Pain Relevance 0.51
The inhibitory effect is reversible and highly specific, since insulin binding to the same membrane preparation is not affected.
Neg (not) Regulation (affected) of insulin Binding (binding) of
6) Confidence 0.17 Published 1984 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6143813 Disease Relevance 0.16 Pain Relevance 0.26
None of the tested substances was found to alter 125I-Insulin binding.
Regulation (alter) of 125I-Insulin Binding (binding) of
7) Confidence 0.06 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 3075186 Disease Relevance 0.17 Pain Relevance 0.86

General Comments

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