INT258135

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.25
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CARTPT) extracellular space (CARTPT) extracellular region (CARTPT)
molecular_function (CARTPT) cell-cell signaling (CARTPT)
Anatomy Link Frequency
neurons 1
CARTPT (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 10 99.48 Very High Very High Very High
Neuropeptide 9 99.06 Very High Very High Very High
noradrenaline 57 98.84 Very High Very High Very High
Dopamine 43 96.56 Very High Very High Very High
Substantia nigra 17 76.12 Quite High
cerebral cortex 10 75.44 Quite High
Neurotransmitter 14 71.44 Quite High
Pain 6 68.64 Quite High
Locus ceruleus 356 68.40 Quite High
Inflammation 9 68.28 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 467 99.84 Very High Very High Very High
Disease 387 98.52 Very High Very High Very High
Disease Progression 12 96.52 Very High Very High Very High
Death 13 95.68 Very High Very High Very High
Syndrome 22 91.32 High High
Dementia 191 90.96 High High
Frailty 10 86.64 High High
Sleep Disorders 87 72.16 Quite High
Pain 4 68.64 Quite High
INFLAMMATION 12 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neuropeptide Cocaine and Amphetamine-Regulated Transcript (CART) is expressed selectively in neurons in the hypothalamic region.
Gene_expression (expressed) of CART in neurons associated with neuropeptide and cocaine
1) Confidence 0.40 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.72 Pain Relevance 0.39
Known coexpressed genes in various species include NTPX2, GAL, PDYN, ENTPD3 (extonucleoside triphosphate diphosphohydrolase 3) and CART.
Gene_expression (coexpressed) of CART
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.36 Pain Relevance 0.04
Interestingly, CSF CART levels correlate with p-tau protein levels, but they do not appear to correlate with the DLB disease progression [71].
Gene_expression (levels) of CART associated with parkinson's disease and disease progression
3) Confidence 0.35 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.56 Pain Relevance 0.34
A study by Schultz et al. [71] reported a significant reduction by 30% in the CSF CART levels in DLB compared to both control and AD subjects.
Gene_expression (levels) of CART associated with parkinson's disease and disease
4) Confidence 0.31 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.61 Pain Relevance 0.34
These drugs produce robust increases in arousal (amphetamine [157, 171]; cocaine [492]).
Gene_expression (produce) of amphetamine associated with cocaine
5) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0 Pain Relevance 0.77

General Comments

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