INT258143

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.93
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt, Atxn3) peptidase activity (Atxn3) endoplasmic reticulum (Hcrt)
nucleus (Atxn3)
Hcrt (Mus musculus)
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 79.44 Quite High
Locus ceruleus 16 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 20 99.76 Very High Very High Very High
Targeted Disruption 86 99.66 Very High Very High Very High
Sleep Disorders 138 99.28 Very High Very High Very High
Disease 8 50.20 Quite High
Gliosis 2 12.88 Low Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of notable interest is a transgenic mouse model where the HCRT promoter drives a form of ataxin-3 containing a large polyglutamine repeat, resulting in HCRT cell death and a narcolepsy-like phenotype at 2–3 weeks of age [6].
HCRT Binding (form) of ataxin-3 associated with targeted disruption, sleep disorders and death
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.99 Pain Relevance 0.04
Of notable interest is a transgenic mouse model where the HCRT promoter drives a form of ataxin-3 containing a large polyglutamine repeat, resulting in HCRT cell death and a narcolepsy-like phenotype at 2–3 weeks of age [6].
HCRT Binding (form) of ataxin-3 associated with targeted disruption, sleep disorders and death
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.94 Pain Relevance 0.04

General Comments

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