INT258144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) endoplasmic reticulum (Hcrt)
nucleus (IGFBP3) cytoplasm (Hcrt)
IGFBP3 (Homo sapiens)
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 2 66.32 Quite High
medulla 4 38.88 Quite Low
Locus ceruleus 16 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 138 98.52 Very High Very High Very High
Death 20 97.96 Very High Very High Very High
Targeted Disruption 86 97.90 Very High Very High Very High
Congenital Anomalies 2 75.76 Quite High
Hyperglycemia 2 72.24 Quite High
Injury 2 66.96 Quite High
Apoptosis 8 55.64 Quite High
Sprains And Strains 10 51.84 Quite High
Disease 8 33.28 Quite Low
Cancer 6 29.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore next explored whether IGFBP3 modulates hypocretin transmission, with complementary in vitro and in vivo functional studies using hIGFBP3 transgenic mice.
IGFBP3 Spec (whether) Regulation (modulates) of Gene_expression (transmission) of hypocretin associated with targeted disruption
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.02 Pain Relevance 0.03
Hypocretin-1 peptide contents were significantly decreased primarily in hIGFBP3 transgenic and less so in humtIGFBP3 transgenic mice compared to controls, indicating both IGF dependent and less prominently independent properties of IGFBP3 affect hypocretin production (Fig 3B).
IGFBP3 Regulation (affect) of Gene_expression (production) of hypocretin associated with targeted disruption
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox