INT258146

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) endoplasmic reticulum (Hcrt)
nucleus (IGFBP3) cytoplasm (Hcrt)
IGFBP3 (Homo sapiens)
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 49.64 Quite Low
Neurotransmitter 3 19.44 Low Low
Locus ceruleus 24 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cocaine 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Dynorphin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 129 100.00 Very High Very High Very High
Death 30 99.96 Very High Very High Very High
Sleep Disorders 207 99.62 Very High Very High Very High
Neuroblastoma 6 96.64 Very High Very High Very High
Disease 12 66.56 Quite High
Sprains And Strains 15 32.00 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we found no IGFBP3 autoantibodies nor a genetic association with IGFBP3 polymorphisms in human narcolepsy, we found that an IGFBP3 polymorphism known to increase serum IGFBP3 levels was associated with lower CSF hypocretin-1 in normal individuals.


IGFBP3 Binding (associated) of hypocretin-1 associated with sleep disorders
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.70 Pain Relevance 0
An IGFBP3 polymorphism known to increase IGFBP3 serum levels is associated with reduced CSF hypocretin levels
IGFBP3 Binding (associated) of hypocretin
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.48 Pain Relevance 0
To assess whether IGFBP3 overexpression could modulate cell death, hIGFBP3 transgenic mice were crossed with Hcrt-ataxin-3 transgenic mice known to develop hypocretin cell loss at 3–6 weeks of age.
hIGFBP3 Binding (crossed) of Hcrt associated with targeted disruption and death
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.85 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox