INT258146

Context Info Confidence 0.23 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.04 Pain Relevance 0

extracellular space (IGFBP3) extracellular region (IGFBP3) endoplasmic reticulum (Hcrt) nucleus (IGFBP3) cytoplasm (Hcrt)

IGFBP3 (Homo sapiens) Hcrt (Mus musculus)

Pain Link Frequency Relevance Heat Neuropeptide 9 49.64 Neurotransmitter 3 19.44 Locus ceruleus 24 5.00 Dopamine 6 5.00 medulla 6 5.00 Analgesic 3 5.00 anesthesia 3 5.00 cocaine 3 5.00 nMDA receptor 3 5.00 Dynorphin 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 129 100.00 Death 30 99.96 Sleep Disorders 207 99.62 Neuroblastoma 6 96.64 Disease 12 66.56 Sprains And Strains 15 32.00 Apoptosis 12 5.00 Cancer 9 5.00 Hypersensitivity 9 5.00 Hypoxia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although we found no IGFBP3 autoantibodies nor a genetic association with IGFBP3 polymorphisms in human narcolepsy, we found that an IGFBP3 polymorphism known to increase serum IGFBP3 levels was associated with lower CSF hypocretin-1 in normal individuals.

IGFBP3 Binding (associated) of hypocretin-1 associated with sleep disorders

1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.70 Pain Relevance 0

An IGFBP3 polymorphism known to increase IGFBP3 serum levels is associated with reduced CSF hypocretin levels

IGFBP3 Binding (associated) of hypocretin

2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.48 Pain Relevance 0

To assess whether IGFBP3 overexpression could modulate cell death, hIGFBP3 transgenic mice were crossed with Hcrt-ataxin-3 transgenic mice known to develop hypocretin cell loss at 3–6 weeks of age.

hIGFBP3 Binding (crossed) of Hcrt associated with targeted disruption and death

3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.85 Pain Relevance 0

General Comments

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