INT258147

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) endoplasmic reticulum (Hcrt)
nucleus (IGFBP3) cytoplasm (Hcrt)
Anatomy Link Frequency
hypothalamus 2
IGFBP3 (Homo sapiens)
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 2 60.08 Quite High
medulla 4 53.04 Quite High
Locus ceruleus 16 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 86 98.76 Very High Very High Very High
Sleep Disorders 138 92.28 High High
Death 20 91.72 High High
Congenital Anomalies 2 89.92 High High
Hyperglycemia 2 86.40 High High
Injury 2 60.72 Quite High
Apoptosis 8 49.40 Quite Low
Cancer 6 23.72 Low Low
Malignant Neoplastic Disease 2 20.48 Low Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that increased IGFBP3 decreases both hypocretin mRNA, and hypocretin peptide content in hypothalamus and target areas (Fig. 3A–C).
IGFBP3 Negative_regulation (decreases) of hypocretin mRNA in hypothalamus
1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.93 Pain Relevance 0.06
We found that increased IGFBP3 decreases both hypocretin mRNA, and hypocretin peptide content in hypothalamus and target areas (Fig. 3A–C).
IGFBP3 Negative_regulation (decreases) of hypocretin peptide in hypothalamus
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.94 Pain Relevance 0.06

General Comments

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