INT258148

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) endoplasmic reticulum (Hcrt)
nucleus (IGFBP3) cytoplasm (Hcrt)
IGFBP3 (Homo sapiens)
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 73.04 Quite High
nMDA receptor 1 48.96 Quite Low
Locus ceruleus 8 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Dynorphin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 1 99.32 Very High Very High Very High
Congenital Anomalies 1 98.44 Very High Very High Very High
Targeted Disruption 43 87.64 High High
Sleep Disorders 69 81.16 Quite High
Death 10 80.60 Quite High
Injury 1 49.60 Quite Low
Apoptosis 4 38.28 Quite Low
Cancer 3 12.60 Low Low
Malignant Neoplastic Disease 1 9.36 Low Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although these effects could be indirectly mediated by minor endocrine abnormalities in these animals, for example hyperglycemia [33], the in vitro findings that IGFBP3 expression suppresses HCRT promotor activity (Fig. 3E) and that the functional IGFBP3 polymorphism rs2854744 is associated with reduced hypocretin transmission, observed as lower levels of Hcrt-1 in human CSF (Fig. 3F), makes this hypothesis unlikely.
Gene_expression (expression) of IGFBP3 Negative_regulation (suppresses) of HCRT associated with hyperglycemia and congenital anomalies
1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.86 Pain Relevance 0.04

General Comments

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