INT258162

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppap2a) plasma membrane (Ppap2a)
Anatomy Link Frequency
paw 2
germ cell 2
Ppap2a (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 20 100.00 Very High Very High Very High
withdrawal 14 99.84 Very High Very High Very High
Antinociceptive 44 94.28 High High
adenocard 48 91.36 High High
Antihyperalgesic 18 90.60 High High
antiallodynic 16 90.52 High High
intrathecal 10 81.96 Quite High
Inflammation 13 79.44 Quite High
agonist 21 79.28 Quite High
antagonist 19 77.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 17 99.72 Very High Very High Very High
Male Infertility 2 98.62 Very High Very High Very High
Apoptosis 15 93.64 High High
Aging 2 90.32 High High
Reprotox - General 1 1 89.52 High High
INFLAMMATION 14 79.44 Quite High
Inflammatory Pain 12 76.44 Quite High
Sleep Disorders 4 72.44 Quite High
Paralysis 8 71.96 Quite High
Infertility 1 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar azoospermia and reduced germ cell numbers were found in transgenic animals that overexpress lipid phosphate phosphatase, an enzyme that degrades LPA (Yue et al., 2004).
Positive_regulation (overexpress) of Gene_expression (overexpress) of lipid phosphate phosphatase in germ cell associated with targeted disruption and male infertility
1) Confidence 0.09 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.69 Pain Relevance 0.11
And, just like hPAP and bPAP mediated antinociception, A1R receptor activation was required for mPAP mediated antinociception.
Positive_regulation (required) of Gene_expression (antinociception) of mPAP associated with antinociception
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.41 Pain Relevance 0.92
In addition, mPAP produced a significant increase in withdrawal threshold to the mechanical stimulus (relative to latency on Day 1, pre-injection) only in the inflamed paw (Fig. 6B, white open circles).
Positive_regulation (increase) of Gene_expression (produced) of mPAP in paw associated with withdrawal
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.30 Pain Relevance 0.85

General Comments

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