INT258167

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Mouse 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 75.84 Quite High
addiction 3 75.80 Quite High
adenocard 72 68.88 Quite High
Antinociceptive 66 60.84 Quite High
Inflammation 18 45.04 Quite Low
tissue acidosis 6 38.96 Quite Low
antiallodynic 24 38.24 Quite Low
Antihyperalgesic 27 37.12 Quite Low
qutenza 3 36.56 Quite Low
ASIC 3 31.36 Quite Low
Disease Link Frequency Relevance Heat
Pain 24 75.84 Quite High
Nociception 24 56.08 Quite High
Injury 6 46.64 Quite Low
INFLAMMATION 18 45.04 Quite Low
Acidosis 12 38.40 Quite Low
Infection 3 20.64 Low Low
Inflammatory Pain 18 5.00 Very Low Very Low Very Low
Paralysis 12 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mouse TM-PAP also dephosphorylated extracellular adenine nucleotides in a pH-dependent manner, although ATP was not a substrate for TM-PAP as it was for secretory PAP.
Phosphorylation (dephosphorylated) of PAP in Mouse
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.13 Pain Relevance 0.16
To determine if TM-PAP could dephosphorylate additional nucleotides extracellularly, and if dephosphorylation was pH dependent, we transfected mouse TM-PAP into HEK 293 cells and stained non-permeabilized cells using enzyme histochemistry.
Phosphorylation (dephosphorylate) of PAP
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0.06
We previously found that the transmembrane isoform of mouse PAP (TM-PAP) could dephosphorylate extracellular AMP at pH 5.6 using enzyme histochemistry, indicating that PAP had ectonucleotidase activity [3].
Phosphorylation (dephosphorylate) of PAP
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0.07

General Comments

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