INT258183

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.33
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GCSH) enzyme binding (GCSH)
Anatomy Link Frequency
brain 1
GCSH (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 99.30 Very High Very High Very High
Central nervous system 1 35.68 Quite Low
gABA 3 19.20 Low Low
Paresthesia 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Electroencephalography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nonketotic Hyperglycinemia 6 100.00 Very High Very High Very High
Hyperglycemia 21 99.08 Very High Very High Very High
Volume Depletion And Dehydration 1 98.48 Very High Very High Very High
Status Epilepticus 1 94.76 High High
Epilepsia Partialis Continua 6 87.04 High High
Metabolic Disorder 2 86.84 High High
Ketosis 2 82.88 Quite High
Dyskinesias 19 81.16 Quite High
Diabetes Mellitus 12 78.80 Quite High
Glycosuria 3 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypotheses have implicated decreased levels of the inhibitory neurotransmitter gamma aminobutyric acid (owing to inhibition of the Krebs cycle in NKH) or direct effects of hyperglycemia, dehydration or hyperosmolarity on the brain, possibly acting on a previously silent cortical lesion to render it epileptogenic [8-10].


Negative_regulation (inhibition) of NKH in brain associated with hyperglycemia, neurotransmitter, volume depletion and dehydration and nonketotic hyperglycinemia
1) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2621138 Disease Relevance 2.33 Pain Relevance 0.05

General Comments

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