INT258203

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0

Golgi apparatus (GTPBP4) GTPase activity (GTPBP4) ribosome biogenesis (GTPBP4) cytoplasm (GTPBP4) signal transducer activity (S1PR1) cell adhesion (S1PR1)

Anatomy Link Frequency neural 1 S1PR1 (Homo sapiens) GTPBP4 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 1 22.64 agonist 11 5.00 Dopamine 3 5.00 dopamine receptor 2 5.00 Clonidine 2 5.00 Neurotransmitter 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Spinal Injuries 1 92.20 Neurodegenerative Disease 2 84.56 Apoptosis 4 60.32 Exencephaly / Neural Tube Defects 3 52.16 Wound Healing 2 19.32 Cancer 3 18.24 Bordatella Infection 5 5.00 Shock 2 5.00 Injury 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LPA and S1P bind and activate cell surface G-protein coupled receptors (GPCRs) to regulate cell proliferation, differentiation, and morphological changes, all of which may contribute to their roles in regulating neural progenitor cell function.

S1P Positive_regulation (activate) of G-protein in neural

1) Confidence 0.00 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.24 Pain Relevance 0

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