INT25822

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Context Info
Confidence 0.29
First Reported 1982
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.43
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 2
pituitary 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 48 100.00 Very High Very High Very High
opioid receptor 5 99.80 Very High Very High Very High
withdrawal 7 98.52 Very High Very High Very High
Neuropeptide 7 98.48 Very High Very High Very High
alcohol 7 97.96 Very High Very High Very High
Morphine 2 94.96 High High
antagonist 10 93.84 High High
Dopamine 3 93.36 High High
Opioid 13 91.68 High High
addiction 1 84.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.56 Very High Very High Very High
Obesity 4 98.90 Very High Very High Very High
Convulsion 6 98.84 Very High Very High Very High
Catalepsy 2 97.44 Very High Very High Very High
Cancer 6 97.36 Very High Very High Very High
Neuroblastoma 2 94.12 High High
Alcohol Addiction 2 89.44 High High
Diabetes Mellitus 5 75.00 Quite High
Syndrome 2 75.00 Quite High
Nociception 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured levels of preproenkephalin (PPE) mRNA and Met-enkephalin peptide in brain and the activity of PTS-1 during alcohol-naive, -dependent, and -withdrawal states.
Negative_regulation (measured) of Positive_regulation (levels) of enkephalin in brain associated with enkephalin, withdrawal and alcohol
1) Confidence 0.29 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11325389 Disease Relevance 0.60 Pain Relevance 1.60
Tumors from mice subjected to either intermittent (4-6h/day; 0.1 mg/kg NTX) or complete (24 h/day; 10 mg/kg NTX) opioid receptor blockade exhibited an up-regulation of DADLE and Met-enkephalin binding sites, as well as tissue levels of beta-endorphin and Met-enkephalin.
Negative_regulation (exhibited) of Positive_regulation (up-regulation) of enkephalin associated with cancer, enkephalin and opioid receptor
2) Confidence 0.23 Published 1989 Journal Brain Res. Section Abstract Doc Link 2540873 Disease Relevance 0.42 Pain Relevance 0.99
If the dipeptidyl carboxypeptidase, inhibited by thiorphan, were located extraneuronally as suggested by De La Baume, Patey and Schwartz (1981), the met5-enkephalin accumulation represents the rate at which the pentapeptide is released extraneuronally.
Negative_regulation (represents) of Positive_regulation (accumulation) of met5-enkephalin associated with enkephalin
3) Confidence 0.22 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.51
Thus, the onset of overt obesity between 4 and 6 wk of age was accompanied by a marked rise in both pancreatic beta-endorphin and pituitary Leu-enkephalin; similar elevations in these parameters have been reported previously in C57BL/6J ob/ob mice at approximately 12 wk of age.
Negative_regulation (rise) of Positive_regulation (pancreatic) of Leu-enkephalin in pituitary associated with obesity and enkephalin
4) Confidence 0.18 Published 1986 Journal Diabetes Section Abstract Doc Link 2944783 Disease Relevance 0.85 Pain Relevance 0.73
Haloperidol-induced increase of striatal enkephalin mRNA is totally abolished in NGFI-B KO mice whereas the increase of neurotensin mRNA expression is reduced by 50%.
Negative_regulation (abolished) of Positive_regulation (increase) of enkephalin mRNA associated with targeted disruption and enkephalin
5) Confidence 0.06 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.48 Pain Relevance 0.54
The potencies of beta-endorphin, [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) and [D-Pen2,5]enkephalin (DPDPE) were reduced after impairing the coupling of mu-ORs to Gi2 or Gz proteins.
Negative_regulation (reduced) of Positive_regulation (potencies) of enkephalin associated with enkephalin
6) Confidence 0.02 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767386 Disease Relevance 0 Pain Relevance 0.83
The potencies of beta-endorphin, [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) and [D-Pen2,5]enkephalin (DPDPE) were reduced after impairing the coupling of mu-ORs to Gi2 or Gz proteins.
Negative_regulation (reduced) of Positive_regulation (potencies) of enkephalin associated with enkephalin
7) Confidence 0.02 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767386 Disease Relevance 0 Pain Relevance 0.83

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