INT258270

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.74
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Anxa5) intracellular (Anxa5) cytoplasm (Anxa5)
Anatomy Link Frequency
apoptotic cells 3
macrophages 1
phagocytes 1
Anxa5 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 37 92.24 High High
Inflammation 41 80.48 Quite High
antagonist 1 75.12 Quite High
positron emission tomography 1 33.44 Quite Low
cytokine 25 17.56 Low Low
Inflammatory response 8 8.04 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 193 98.28 Very High Very High Very High
Toxicity 6 97.84 Very High Very High Very High
Pancreatic Cancer 61 97.60 Very High Very High Very High
Neuroblastoma 55 97.32 Very High Very High Very High
Skin Cancer 53 96.96 Very High Very High Very High
Cancer 473 95.92 Very High Very High Very High
Death 46 92.80 High High
INFLAMMATION 50 80.48 Quite High
Colon Cancer 3 75.76 Quite High
Lymphatic System Cancer 10 74.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This event occurred concomitantly with the binding of Annexin V to phosphatidylserine and the formation of a typical DNA ladder, which is the hallmark of apoptotic cells (Figure S6).
Annexin V Binding (binding) of in apoptotic cells associated with apoptosis
1) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.96 Pain Relevance 0.04
Further, we utilized Annexin V – a protein known to selectively bind to PS (but not to PC) and mask PS recognition and uptake by macrophages.
Annexin V Neg (not) Binding (bind) of in macrophages
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2634966 Disease Relevance 0 Pain Relevance 0
To determine whether the observed D1- and D6-induced reduction in viability of both melanoma and neuroblastoma cell lines occurred via activation of apoptosis, we used TUNEL staining to highlight DNA fragmentation and Annexin-V assay, in which Annexin-V binds to externalized phosphatidylserine on the surface of apoptotic cells.
Annexin-V Binding (binds) of in apoptotic cells associated with neuroblastoma, apoptosis and skin cancer
3) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.31 Pain Relevance 0
Our data indicate that eclipsing of PS with its specific ligand, Annexin V, completely blocks SWCNT recognition by macrophage cell lines and primary phagocytes.
Annexin V Binding (ligand) of in phagocytes
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2634966 Disease Relevance 0.08 Pain Relevance 0.04
Annexin V and Tunnel assays
Annexin V Binding (assays) of
5) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.33 Pain Relevance 0
Radiolabeled recombinant annexin V, which binds phosphatidylserine everted on the exterior surface of apoptotic cells, has been investigated extensively as an in vivo marker of apoptosis [15]–[17], although annexin V also detects necrotic cells [18].
recombinant annexin V Binding (binds) of in apoptotic cells associated with apoptosis
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

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