INT258272

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Context Info
Confidence 0.53
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 99.00 Very High Very High Very High
antagonist 2 98.84 Very High Very High Very High
Arthritis 2 55.36 Quite High
ischemia 2 53.36 Quite High
Inflammation 20 36.92 Quite Low
cytokine 10 6.40 Low Low
ketamine 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 410 98.42 Very High Very High Very High
Apoptosis 16 93.64 High High
Targeted Disruption 8 82.08 Quite High
Stroke 2 77.76 Quite High
Liver Disease 2 76.64 Quite High
Hepatitis Virus Infection 2 74.40 Quite High
Autoimmune Disease 2 73.32 Quite High
Glioblastoma 60 71.60 Quite High
Infection 2 66.44 Quite High
Colon Cancer 4 64.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether HMGB1, released from dying GL26 tumor cells (Ad-TK + GCV treated), was responsible for TLR2 activation in vitro, we inhibited HMGB1 binding using glycyrrhizin, a known antagonist of HMGB1 [40,63].
Negative_regulation (inhibited) of HMGB1 Binding (binding) of associated with cancer and antagonist
1) Confidence 0.53 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.90 Pain Relevance 0.05
Glycyrrhizin binds to both box domains within HMGB1 [40,63] and thus prevents subsequent HMGB1 signaling; specific polyclonal blocking antibodies to HMGB1 [39,77–80] inactivate HMGB1 by binding to it, and reducing its bioavailability.
Negative_regulation (prevents) of HMGB1 Binding (binding) of associated with bioavailability
2) Confidence 0.39 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.92 Pain Relevance 0.10

General Comments

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