INT258280

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

tk (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 25.00 Low Low
headache 1 25.00 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 205 98.96 Very High Very High Very High
Disease 1 78.96 Quite High
Brain Tumor 47 75.00 Quite High
Fibromyalgia 3 59.28 Quite High
Glioblastoma 30 46.16 Quite Low
Glioma 23 25.00 Low Low
Melanoma 8 25.00 Low Low
Death 7 25.00 Low Low
Targeted Disruption 4 25.00 Low Low
Immunotherapy Of Cancer 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The researchers reveal that TLR2 was responding to high-mobility-group box 1 (HMGB1), a protein released by the dying tumor cells by showing that treatment of the tumor-bearing mice with the HMGB1 inhibitor glycyrrhizin blocked the therapeutic effect of Flt3L/TK expression.
Negative_regulation (blocked) of Gene_expression (expression) of TK associated with cancer
1) Confidence 0.14 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.29 Pain Relevance 0

General Comments

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