INT258281

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.21
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
GBM 1
T lymphocytes 1
tk (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 5 85.60 High High
antagonist 5 83.24 Quite High
ischemia 5 71.76 Quite High
Arthritis 5 70.80 Quite High
Inflammation 50 70.28 Quite High
ketamine 10 62.68 Quite High
Bioavailability 5 49.72 Quite Low
agonist 10 28.00 Quite Low
anesthesia 5 26.08 Quite Low
cytokine 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1025 99.98 Very High Very High Very High
Infection 28 99.90 Very High Very High Very High
Glioblastoma 150 99.74 Very High Very High Very High
Glioma 115 99.72 Very High Very High Very High
Melanoma 40 97.28 Very High Very High Very High
Brain Tumor 235 96.40 Very High Very High Very High
Sprains And Strains 40 92.64 High High
Autoimmune Disease 5 89.04 High High
Pox Virus Infection 6 85.80 High High
Stroke 5 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trp2180–188, a known H2-Kb-restricted melanoma tumor antigen shared by glioma tumors such as GL26 cells [47,48], also induced proliferation of T lymphocytes from glioma-bearing mice treated with Flt3L and TK (*, p < 0.05 versus saline; ?
TK Binding (treated) of in T lymphocytes associated with cancer, melanoma and glioma
1) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.45 Pain Relevance 0
HMGB1 was increased in the serum of tumor-bearing mice 7 d after treatment with Flt3L and TK (*p < 0.05; ?
TK Binding (bearing) of associated with cancer
2) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.80 Pain Relevance 0.04
Mice treated with Ad-TK also received 25 ?
TK Binding (received) of
3) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.54 Pain Relevance 0.12
Importantly, HMGB1 released from dying GBM cells after treatment with TK (+GCV), on its own, was insufficient to induce tumor regression in our model.
TK Binding (treatment) of in GBM associated with cancer and glioblastoma
4) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.40 Pain Relevance 0.07
Here we show that dying glioma cells released HMGB1, as a result of infection and killing with Ad-TK (+GCV); HMGB1 in turn stimulated TLR2-dependent NF?
TK Binding (killing) of associated with infection and glioma
5) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.01 Pain Relevance 0.04
BS-C-1, TK?
TK Binding (BS-C-1) of
6) Confidence 0.04 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 1.01 Pain Relevance 0

General Comments

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