INT258282

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.71
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
immune cells 2
tk (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
ischemia 1 38.20 Quite Low
Arthritis 1 37.24 Quite Low
Bioavailability 1 16.16 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 205 99.80 Very High Very High Very High
Brain Tumor 47 98.72 Very High Very High Very High
Glioma 23 95.88 Very High Very High Very High
Melanoma 8 95.44 Very High Very High Very High
Death 7 83.60 Quite High
Glioblastoma 30 65.92 Quite High
Hemorrhagic Shock 1 41.52 Quite Low
Reperfusion Injury 1 38.96 Quite Low
Sepsis 1 37.56 Quite Low
Arthritis 1 37.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, both Flt3L-induced recruitment of immune cells to the brain and TK-dependent release of the TLR2 agonist HMGB1 are necessary for tumor elimination; together, they are sufficient to induce the regression of a large intracranial glioma and melanoma tumors.
Positive_regulation (necessary) of Localization (recruitment) of TK in immune cells associated with melanoma, cancer, agonist and glioma
1) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.71 Pain Relevance 0.05

General Comments

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