INT258289

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.61
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmgb1, Tlr2) cell morphogenesis (Hmgb1) intracellular (Tlr2)
DNA binding (Hmgb1) signal transduction (Tlr2) extracellular space (Hmgb1)
Anatomy Link Frequency
brain 1
Hmgb1 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 10 84.40 Quite High
Inflammation 109 71.36 Quite High
tolerance 10 58.88 Quite High
cytokine 30 56.40 Quite High
ischemia 11 49.28 Quite Low
antagonist 9 35.36 Quite Low
chemokine 6 28.64 Quite Low
Inflammatory response 19 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 65 99.96 Very High Very High Very High
Cancer 289 99.00 Very High Very High Very High
Brain Tumor 48 97.96 Very High Very High Very High
Colon Cancer 2 95.96 Very High Very High Very High
Lymphatic System Cancer 3 94.96 High High
Lewis Lung Carcinoma 2 94.32 High High
Metastasis 49 93.36 High High
American Trypanosomiasis 2 85.36 High High
Glioma 23 84.12 Quite High
Bacterial Respiratory Disease 2 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMGB1 can also activate TLR2 in addition to TLR4 and differential TLR activation appears to depend on the particular tumor model used [58].
HMGB1 Positive_regulation (activate) of TLR2 associated with cancer
1) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.00 Pain Relevance 0
However, it is also reported that activation of TLR2 by endogenous HMGB1 contributes to the anti-tumor immunity against to brain tumor [25].
HMGB1 Positive_regulation (activation) of TLR2 in brain associated with cancer and brain tumor
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.19 Pain Relevance 0.03
Among these, Gp96 and HMGB1 activate TLR2 and 4, whereas fibronectin EDA (FNEDA) and saturated fatty acids activate TLR4 [17, 20, 22, 81–86].
HMGB1 Positive_regulation (activate) of TLR2
3) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.06 Pain Relevance 0.04
We have reported that in HS, HMGB1 through TLR4 signaling upregulates TLR2 in ECs, and this upregulation associates with an amplified EC function including augmented activation of NADPH oxidase and expression of ICAM-1 in response to TLR2 activation by HMGB1 [48].
HMGB1 Positive_regulation (activation) of TLR2 associated with hemorrhagic shock
4) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.62 Pain Relevance 0.09
We have reported that in HS, HMGB1 through TLR4 signaling upregulates TLR2 in ECs, and this upregulation associates with an amplified EC function including augmented activation of NADPH oxidase and expression of ICAM-1 in response to TLR2 activation by HMGB1 [48].
HMGB1 Positive_regulation (upregulates) of TLR2 associated with hemorrhagic shock
5) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

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