INT258290

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmgb1, Tlr2) cell morphogenesis (Hmgb1) intracellular (Tlr2)
DNA binding (Hmgb1) signal transduction (Tlr2) extracellular space (Hmgb1)
Hmgb1 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 97.36 Very High Very High Very High
cytokine 5 11.04 Low Low
Inflammation 10 10.64 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 205 100.00 Very High Very High Very High
Apoptosis 8 98.28 Very High Very High Very High
Colon Cancer 2 69.24 Quite High
Glioblastoma 30 68.64 Quite High
Lymphatic System Cancer 3 68.24 Quite High
Glioma 23 57.40 Quite High
Brain Tumor 47 50.00 Quite Low
INFLAMMATION 9 10.64 Low Low
Melanoma 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether HMGB1, released from dying GL26 tumor cells (Ad-TK + GCV treated), was responsible for TLR2 activation in vitro, we inhibited HMGB1 binding using glycyrrhizin, a known antagonist of HMGB1 [40,63].
HMGB1 Spec (whether) Regulation (responsible) of Positive_regulation (activation) of TLR2 associated with cancer and antagonist
1) Confidence 0.46 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.04 Pain Relevance 0.05

General Comments

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