INT25831

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 2.73
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
neuronal 1
neuronal stem cells 1
brain 1
forebrain 1
melanocytes 1
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 300 100.00 Very High Very High Very High
midbrain 89 100.00 Very High Very High Very High
Enkephalin 10 99.66 Very High Very High Very High
Opioid 15 99.60 Very High Very High Very High
melanocortin 1 receptor 4 99.36 Very High Very High Very High
agonist 12 95.36 Very High Very High Very High
Nucleus accumbens 4 95.00 High High
Glutamate receptor 10 91.28 High High
Ventral tegmentum 17 88.92 High High
Action potential 26 81.84 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 50 99.60 Very High Very High Very High
Opiate Addiction 16 99.48 Very High Very High Very High
Skin Cancer 9 83.00 Quite High
Apoptosis 16 79.92 Quite High
Congenital Anomalies 9 75.00 Quite High
Low Back Pain 6 73.88 Quite High
Neurodegenerative Disease 38 67.80 Quite High
Death 22 63.44 Quite High
Targeted Disruption 36 50.00 Quite Low
Sprains And Strains 6 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of Nurr1 associated with dopamine and opiate addiction
1) Confidence 0.74 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.25 Pain Relevance 0.42
Moreover, the results revealed an exaggerated reduction of Nurr1 expression with age in heroin users (r = -0.8268, p < 0.001 vs controls, r = -0.6204, p = 0.0746).
Gene_expression (expression) of Nurr1 associated with opiate addiction
2) Confidence 0.74 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.41 Pain Relevance 0.73
Evidence for the presence of mu- and kappa- but not of delta-opioid sites in the human fetal brain.
Gene_expression (presence) of not in brain associated with enkephalin and opioid
3) Confidence 0.65 Published 1989 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 2540923 Disease Relevance 0 Pain Relevance 1.18
A NotI-XhoI fragment from pBS-ADan2.9, comprising the RA, was inserted into NotI and SacII sites of a Soriano PGK-Neo-dTA vector (blunt-ended by the SacII and XhoI digestion followed by treatment of T4-exonuclease and Klenow polymerase respectively) at 5?
Gene_expression (sites) of NotI associated with rheumatoid arthritis
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.20 Pain Relevance 0
Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.
Gene_expression (expression) of NR4A nuclear receptor associated with melanocortin 1 receptor
5) Confidence 0.64 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 18292087 Disease Relevance 0.32 Pain Relevance 0.23
Using small interference RNA-mediated attenuation of NR4A1 and NR4A2 expression in melanocytes, the ability to remove cyclobutane pyrimidine dimers following UV irradiation appeared to be impaired in the context of MC1R signaling.
Gene_expression (expression) of NR4A2 in melanocytes
6) Confidence 0.64 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18292087 Disease Relevance 0.30 Pain Relevance 0.18
The generated exon 2+3 construct and exon 8+9 construct were digested with SacI and NotI and subcloned into SacI and BamHI digested pEGFP-C3 and pEGFP-C2 (Clontech, Palo Alto, CA), respectively, each with a synthesized BglII-NotI linker.


Gene_expression (synthesized) of NotI
7) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Significant alteration of the mRNA expression of Nurr1, a transcription factor that regulates DAT expression, was also confined to the PN.
Gene_expression (expression) of Nurr1
8) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.39 Pain Relevance 0.56
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of nuclear receptor-related 1 associated with dopamine and opiate addiction
9) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.25 Pain Relevance 0.42
It was already reported that co-culture of nonhuman primate ESC with the mouse bone marrow mesenchymal PA6 cells (SDIA) results in TH+ midbrain neuronal cell lineage expressing NURR1 and LMX1B genes [8], [44], [53].
Gene_expression (expressing) of NURR1 in neuronal associated with midbrain
10) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.18
In contrast, we observed very weak expression of transcripts EN1, characteristic for midbrain cells [28] and NURR1 that has a role in the differentiation of midbrain precursors into dopamine neurons [29]–[32], revealing possible forebrain character of generated cells.
Gene_expression (expression) of NURR1 in forebrain associated with dopamine and midbrain
11) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.25
Underexpression of NR4A2, tumour necrosis factor AIP3 (TNFAIP3) and CD69 was confirmed.
Gene_expression (Underexpression) of NR4A2
12) Confidence 0.28 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 19643760 Disease Relevance 0.07 Pain Relevance 0
More interestingly, in comparison of genes associated during neural differentiation process of human embryonic stem cells or human brain with our results, we also found increased expression of PENK, STK4, IGFBP4, Slc17a6, Slc6A1, Nurr1, Nrp2, Moxd1, Shh and Neurod2 [36,37].
Gene_expression (expression) of Nurr1 in neural
13) Confidence 0.19 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0
RT-PCR and western blot analysis confirmed the expression of midbrain specific markers, including engrailed 1, Nurr1, Pitx3, and dopamine transporter (DAT) in cultures influenced by these four molecules.
Gene_expression (expression) of Nurr1 in midbrain associated with dopamine and midbrain
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.17
Nurr1 was also detected in untreated cultures, but was increased by SPIE.
Gene_expression (detected) of Nurr1
15) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.25
Western blot analysis confirmed expression of the MAP2, Nuclear receptor 1 (Nurr1), and TH proteins (Fig. 5B).
Gene_expression (expression) of Nurr1
16) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
Thus, higher yields of dopaminergic neurons were obtained when neuronal stem cells overexpressing Nurr1 (Grothe et al., 2004) or monkey ESCs (Takagi et al., 2005) were differentiated in the presence of FGF-20.
Gene_expression (overexpressing) of Nurr1 in neuronal stem cells
17) Confidence 0.12 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.13 Pain Relevance 0.08
In each tissue, Nurr2 is expressed at significantly lower levels than Nurr1.


Gene_expression (expressed) of Nurr1
18) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0
Nurr1 and Nurr2 are expressed ubiquitously in all examined tissues in these species [Ohkura et al., 1999].
Gene_expression (expressed) of Nurr1
19) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0
Nurr1 and Nurr2 are expressed ubiquitously in all examined tissues in these species [Ohkura et al., 1999].
Gene_expression (expressed) of Nurr2
20) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0

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