INT258311

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 8.51
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
neuronal 2
lymph node 2
B cells 2
lymphoid tissue 2
synovium 2
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 981 100.00 Very High Very High Very High
Eae 80 94.32 High High
Inflammation 81 69.60 Quite High
Arthritis 9 56.40 Quite High
cINOD 9 25.00 Low Low
Pain 9 25.00 Low Low
chemokine 27 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
Etanercept 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 981 100.00 Very High Very High Very High
Disease 305 99.64 Very High Very High Very High
Targeted Disruption 184 99.64 Very High Very High Very High
Syndrome 18 99.42 Very High Very High Very High
Salivary Gland Disease 18 98.36 Very High Very High Very High
Apoptosis 48 98.08 Very High Very High Very High
Autoimmune Disease 99 91.16 High High
Amyloid Plaque 24 76.12 Quite High
Alzheimer's Dementia 64 75.00 Quite High
INFLAMMATION 90 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AID overexpression in our model is very high, as determined by Real Time PCR, and as evident from WB analysis [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.41 Pain Relevance 0.04
By evaluating the expression of CD21L and AID mRNA using QT-PCR, a sensitive and highly specific method, we were able to identify functional sites of ectopic lymphoneogenesis in about 50% of the RA synovial samples.
Positive_regulation (evaluating) of Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
2) Confidence 0.46 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.42 Pain Relevance 0.08
A previous analysis of these mice showed that overexpression of AID did not affect gene transcription.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.64 Pain Relevance 0.03
In conclusion, our transgenic model shows that overexpression of several isoforms of AID in the CNS fails to reproduce obvious signs of AD-like pathology in mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID associated with targeted disruption and disease
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.93 Pain Relevance 0.03
Both CSR and SHM are initiated by and critically dependent upon the expression of the enzyme activation-induced cytidine deaminase (AID) [17].
Positive_regulation (dependent) of Gene_expression (expression) of activation-induced cytidine deaminase
5) Confidence 0.43 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.13 Pain Relevance 0.04
-actin, Figure 2B) were seen in samples positive for AID and CD21L by QT-PCR (lane 2) and human lymph node (lane 5), but not in RA samples negative for AID and CD21L (lane 3) or in the negative control (lane 4, cDNA from CD3 sorted cells).
Positive_regulation (positive) of Neg (negative) Gene_expression (negative) of AID in lymph node associated with rheumatoid arthritis
6) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.25
Indeed, as further evidence of AID functionality within synovial tissue, we demonstrated that AID expression supports the expression of I?
Positive_regulation (supports) of Gene_expression (expression) of AID
7) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.23
To test whether these B cells were derived from AID-expressing cells resident in the synovium rather than ACPA-expressing immune system cells coming into the synovium from elsewhere in the body, the researchers transplanted synovium from patients with rheumatoid arthritis under the skin of a special sort of mouse that largely lacks its own immune system.
Spec (whether) Positive_regulation (derived) of Gene_expression (expressing) of AID in synovium associated with rheumatoid arthritis
8) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.43 Pain Relevance 0.15
Both CSR and SHM are initiated by and critically dependent upon the expression of the enzyme activation-induced cytidine deaminase (AID) [17].
Positive_regulation (dependent) of Gene_expression (expression) of AID
9) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.13 Pain Relevance 0.04
We have found no evidence that AID overexpression induces AD-like characteristics, such as activation of GSK-3?
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID associated with disease
10) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905372 Disease Relevance 1.30 Pain Relevance 0
This evidence suggests that AID overexpression may predispose to neuronal degeneration.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID in neuronal
11) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.61 Pain Relevance 0.04
Another model of AID59 overexpression [22], [28] shows GSK3?
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID59
12) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.32 Pain Relevance 0.08
Later phosphorylations (PHF1 Ser396/404) are not influenced by AID overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AID
13) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0 Pain Relevance 0.09
APP processing occurring in axonal extensions and/or synapses, leading to regional production of AID, may play a physiological role that, if disregulated, could lead to synaptic disfunction.
Positive_regulation (leading) of Gene_expression (production) of AID in synapses
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.72 Pain Relevance 0.04
Indeed, AID mRNA expression was detected in all 12 of the CD21L+ RA samples but in none of the 13 CD21L?
Positive_regulation (detected) of Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
15) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.25
Recent evidence has demonstrated that the processes of SHM and CSR are critically dependent on the expression of the enzyme AID [17] and that AID expression is exclusively associated with B cells undergoing SHM and CSR [52].
Positive_regulation (dependent) of Gene_expression (expression) of AID in B cells
16) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.61 Pain Relevance 0.28
These results confirm and expand our recent observations in Sjögren's syndrome [42] in which FDCs appeared necessary for sustaining AID expression in the ectopic lymphoid tissue found in salivary glands, where an antigen-driven B cell response can occur [53].
Positive_regulation (necessary) of Gene_expression (expression) of AID in lymphoid tissue associated with salivary gland disease and syndrome
17) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.36 Pain Relevance 0.08

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