INT258312

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.88
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
B cells 1
nucleus 1
T cell 1
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 327 87.72 High High
Eae 10 56.20 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 6 90.00 High High
Rheumatoid Arthritis 327 87.72 High High
Targeted Disruption 23 86.72 High High
Syndrome 6 86.56 High High
Apoptosis 6 80.56 Quite High
Autoimmune Disease 33 76.24 Quite High
Disease 55 56.76 Quite High
Alzheimer's Dementia 8 50.00 Quite Low
Severe Combined Immunodeficiency 48 5.00 Very Low Very Low Very Low
INFLAMMATION 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other side, it has been suggested that AID, recruiting Fe65 to the plasma membrane, is then able to release it and allow its transcriptional function to take part in the nucleus, with or without Tip60 [11], [17], [46].
Localization (recruiting) of AID in nucleus
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.29 Pain Relevance 0.03
The morphological appearance, tissue distribution, and predominant cytoplasmic AID expression in these cells (Figure 3E and 3F) closely resembles the population of IF large B cells recently described in lymph nodes [22] where AID+ IF large B cells are mainly localised within the T cell area surrounding the follicles [21,23].


Localization (localised) of AID in B cells
2) Confidence 0.60 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.06 Pain Relevance 0.03
In addition, they share many similarities with IF large B cells in secondary lymphoid organs, namely their localisation within the peripheral T cell area, a predominantly cytoplasmic AID staining pattern and a dendritic morphology [22].
Localization (localisation) of AID in T cell
3) Confidence 0.60 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.34 Pain Relevance 0.04
Conversely, although APRIL mRNA showed an increase in AID+ synovial tissue, these differences did not reach statistical significance (Figure 2E).


Localization (tissue) of AID
4) Confidence 0.60 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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