INT258313

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.14
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
lymph node 1
B cell 1
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 545 97.12 Very High Very High Very High
cytokine 5 96.28 Very High Very High Very High
Etanercept 5 87.36 High High
Infliximab 5 83.76 Quite High
chemokine 15 80.52 Quite High
Eae 10 69.36 Quite High
Inflammation 45 48.56 Quite Low
methotrexate 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 545 97.12 Very High Very High Very High
Targeted Disruption 23 91.28 High High
Synovitis 25 72.24 Quite High
Severe Combined Immunodeficiency 80 71.44 Quite High
Disease 73 68.00 Quite High
Alzheimer's Dementia 8 50.00 Quite Low
Arthritis 10 49.44 Quite Low
INFLAMMATION 50 48.56 Quite Low
Apoptosis 6 43.76 Quite Low
Autoimmune Disease 55 5.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both CSR and SHM are initiated by and critically dependent upon the expression of the enzyme activation-induced cytidine deaminase (AID) [17].
Positive_regulation (dependent) of activation-induced cytidine deaminase
1) Confidence 0.46 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.13 Pain Relevance 0.04
The AID50 is reputed the naturally occurring AID fragment.
Positive_regulation (occurring) of AID
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.47 Pain Relevance 0.03
mRNA [26], we then sought to determine whether the expression levels of these and other key factors involved in lymphoneogenesis were also significantly associated with the up-regulation of AID and CD21L mRNA.
Positive_regulation (regulation) of AID
3) Confidence 0.43 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.22 Pain Relevance 0.11
Both CSR and SHM are initiated by and critically dependent upon the expression of the enzyme activation-induced cytidine deaminase (AID) [17].
Positive_regulation (dependent) of AID
4) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.13 Pain Relevance 0.04
-actin, Figure 2B) were seen in samples positive for AID and CD21L by QT-PCR (lane 2) and human lymph node (lane 5), but not in RA samples negative for AID and CD21L (lane 3) or in the negative control (lane 4, cDNA from CD3 sorted cells).
Positive_regulation (positive) of AID in lymph node associated with rheumatoid arthritis
5) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.45 Pain Relevance 0.22
We suggest that the up-regulation of these key cytokines within RA synovial tissue allows differentiation and maintenance of FDC networks within T/B cell aggregates to form functional microanatomical immunological units, and hence, allow the up-regulation of AID and subsequent production of ACPA.
Positive_regulation (up-regulation) of AID in B cell associated with rheumatoid arthritis and cytokine
6) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.74 Pain Relevance 0.41

General Comments

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