INT258315

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
lymphoid tissue 2
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 436 99.68 Very High Very High Very High
chemokine 12 75.28 Quite High
Inflammation 36 61.52 Quite High
Arthritis 4 11.44 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Etanercept 4 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 436 99.68 Very High Very High Very High
Syndrome 8 99.14 Very High Very High Very High
Salivary Gland Disease 8 98.36 Very High Very High Very High
Severe Combined Immunodeficiency 64 69.00 Quite High
INFLAMMATION 40 61.52 Quite High
Synovitis 20 40.64 Quite Low
Autoimmune Disease 44 26.08 Quite Low
Arthritis 8 11.44 Low Low
Disease 36 8.16 Low Low
Frailty 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, even low-level expression of AID and CD21L within the transplants was still associated with significant ACPA detection in the sera, while ACPA were barely detectable in the absence of AID mRNA expression in the RA grafts.
Negative_regulation (absence) of Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
1) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.23
The levels of ACPA decreased in line with the decrease of AID mRNA expression, whilst no ACPA were detected in AID?
Negative_regulation (decrease) of Gene_expression (expression) of AID mRNA
2) Confidence 0.40 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.40 Pain Relevance 0.20
To evaluate whether the sustained expression of AID and CD21L mRNA in RA synovial grafts was associated with dynamic gene expression regulating ectopic lymphoneogenesis, we analysed mRNA expression levels of CXCL13, LT?
Spec (whether) Negative_regulation (sustained) of Gene_expression (expression) of AID associated with rheumatoid arthritis
3) Confidence 0.39 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.50 Pain Relevance 0.29
These results confirm and expand our recent observations in Sjögren's syndrome [42] in which FDCs appeared necessary for sustaining AID expression in the ectopic lymphoid tissue found in salivary glands, where an antigen-driven B cell response can occur [53].
Negative_regulation (sustaining) of Gene_expression (expression) of AID in lymphoid tissue associated with salivary gland disease and syndrome
4) Confidence 0.35 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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