INT25832

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 9
Total Number 9
Disease Relevance 3.59
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kitl) extracellular region (Kitl) cell adhesion (Kitl)
plasma membrane (Kitl) cytoskeleton (Kitl) cytoplasm (Kitl)
Anatomy Link Frequency
neurons 1
skin 1
thoracic 1
dorsal horn 1
midbrain 1
Kitl (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 37 100.00 Very High Very High Very High
midbrain 2 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
local anesthetic 1 99.98 Very High Very High Very High
Dorsal horn 3 99.84 Very High Very High Very High
withdrawal 20 99.34 Very High Very High Very High
Raphe 2 99.12 Very High Very High Very High
spinal dorsal horn 2 99.08 Very High Very High Very High
wide dynamic range 3 98.92 Very High Very High Very High
Migraine 5 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 37 100.00 Very High Very High Very High
Staphylococcus Infection 2 99.68 Very High Very High Very High
Nociception 7 99.56 Very High Very High Very High
Headache 4 97.32 Very High Very High Very High
Migraine With Aura 1 92.56 High High
Pain 3 83.00 Quite High
Opiate Addiction 7 79.52 Quite High
Attention Deficit Hyperactivity Disorder 1 75.84 Quite High
Infection 78 50.00 Quite Low
Sepsis 13 31.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of Con A was dependent on its concentration and was inhibited by alpha-methyl-D-mannoside.
Negative_regulation (inhibited) of Con
1) Confidence 0.43 Published 1982 Journal J. Submicrosc. Cytol. Section Abstract Doc Link 7077713 Disease Relevance 0 Pain Relevance 0.32
A decrease in animal weight, with a peak occurring at 24 hours following withdrawal induction, and a time-dependent suppression of concalavalin A (Con-A) and toxic shock syndrome toxin (TSST)-1-stimulated splenic T-cell proliferation, Con-A-stimulated splenocyte, IFN-?
Negative_regulation (suppression) of Con in T-cell associated with staphylococcus infection and withdrawal
2) Confidence 0.09 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.41 Pain Relevance 1.35
One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in the production of IL-2.
Negative_regulation (inhibited) of ConA
3) Confidence 0.01 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9916880 Disease Relevance 0 Pain Relevance 0.09
Inhibition of the MSR was only elicited ipsilaterally and that of PSR was reduced by about 50% on stimulation of the contralateral thoracic cord; inhibition of CON FAST could be evoked from either side of the cord.
Negative_regulation (inhibition) of CON FAST in thoracic
4) Confidence 0.00 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.14
Local anesthetic block of the mesencephalic periaqueductal gray (PAG) and/or nucleus raphe dorsalis (NRD) eliminated the inhibitory effects of vagal stimulation on the responses of both classes of TP neurons to TTT stimulation.
Negative_regulation (block) of periaqueductal gray in neurons associated with raphe, central grey and local anesthetic
5) Confidence 0.00 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375683 Disease Relevance 0.27 Pain Relevance 0.56
Blockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity.
Negative_regulation (Blockade) of periaqueductal gray in midbrain associated with nociception, nociceptor, spinal dorsal horn, midbrain and central grey
6) Confidence 0.00 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2540988 Disease Relevance 0.37 Pain Relevance 0.55
Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats.
Negative_regulation (inhibition) of periaqueductal gray in dorsal horn associated with dorsal horn and central grey
7) Confidence 0.00 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8764343 Disease Relevance 0.59 Pain Relevance 0.77
P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?
Negative_regulation (blockade) of periaqueductal gray associated with nociception, migraine and central grey
8) Confidence 0.00 Published 2002 Journal J. Neurosci. Section Title Doc Link 11880534 Disease Relevance 1.19 Pain Relevance 0.83
Periaqueductal gray inhibition of viscerointercostal and galvanic skin reflexes.
Negative_regulation (inhibition) of Periaqueductal gray in skin associated with central grey
9) Confidence 0.00 Published 1986 Journal Brain Res. Section Title Doc Link 3697757 Disease Relevance 0.76 Pain Relevance 0.46

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