INT258321

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
B cells 2
lymphoid tissue 2
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 436 100.00 Very High Very High Very High
chemokine 12 79.44 Quite High
Inflammation 36 61.12 Quite High
cINOD 4 25.00 Low Low
Pain 4 25.00 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Etanercept 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 436 100.00 Very High Very High Very High
INFLAMMATION 40 61.12 Quite High
Autoimmune Disease 44 51.04 Quite High
Severe Combined Immunodeficiency 64 45.72 Quite Low
Synovitis 20 44.80 Quite Low
Infection 8 38.72 Quite Low
Disease 36 25.00 Low Low
Pressure And Volume Under Development 4 25.00 Low Low
Arthralgia 4 25.00 Low Low
Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate whether the sustained expression of AID and CD21L mRNA in RA synovial grafts was associated with dynamic gene expression regulating ectopic lymphoneogenesis, we analysed mRNA expression levels of CXCL13, LT?
Spec (whether) Regulation (associated) of Gene_expression (expression) of AID associated with rheumatoid arthritis
1) Confidence 0.42 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.30
Indeed, AID mRNA expression was detected in all 12 of the CD21L+ RA samples but in none of the 13 CD21L?
Regulation (detected) of Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
2) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.25
Four weeks later, the researchers found that the transplanted human lymphoid tissue was still making AID, that the level of AID expression correlated with the amount of human ACPA in the blood of the mice, and that the B cells in the transplant were proliferating.


Regulation (level) of Gene_expression (expression) of AID in lymphoid tissue
3) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.40 Pain Relevance 0.17
The morphological appearance, tissue distribution, and predominant cytoplasmic AID expression in these cells (Figure 3E and 3F) closely resembles the population of IF large B cells recently described in lymph nodes [22] where AID+ IF large B cells are mainly localised within the T cell area surrounding the follicles [21,23].


Regulation (population) of Gene_expression (expression) of AID in B cells
4) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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