INT258328

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Context Info
Confidence 0.71
First Reported 2009
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 76
Total Number 103
Disease Relevance 58.29
Pain Relevance 16.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Aicda) nucleus (Aicda) cytoplasm (Aicda)
Anatomy Link Frequency
B cells 14
synovium 13
forebrain 5
lymphoid tissue 4
plasma cells 2
Aicda (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 8720 100.00 Very High Very High Very High
Hippocampus 23 98.30 Very High Very High Very High
Inflammation 720 98.24 Very High Very High Very High
Eae 230 95.12 Very High Very High Very High
chemokine 240 76.52 Quite High
Arthritis 80 55.72 Quite High
cINOD 80 39.64 Quite Low
isoflurane 23 39.52 Quite Low
anesthesia 23 38.64 Quite Low
methotrexate 80 38.40 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 8720 100.00 Very High Very High Very High
Targeted Disruption 529 100.00 Very High Very High Very High
Disease 1364 99.64 Very High Very High Very High
Urological Neuroanatomy 23 99.10 Very High Very High Very High
Neurodegenerative Disease 69 99.06 Very High Very High Very High
Syndrome 160 98.92 Very High Very High Very High
Severe Combined Immunodeficiency 1280 98.50 Very High Very High Very High
Salivary Gland Disease 160 98.36 Very High Very High Very High
INFLAMMATION 800 98.24 Very High Very High Very High
Apoptosis 138 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, even low-level expression of AID and CD21L within the transplants was still associated with significant ACPA detection in the sera, while ACPA were barely detectable in the absence of AID mRNA expression in the RA grafts.
Gene_expression (expression) of AID associated with rheumatoid arthritis
1) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.47 Pain Relevance 0.20
By evaluating the expression of CD21L and AID mRNA using QT-PCR, a sensitive and highly specific method, we were able to identify functional sites of ectopic lymphoneogenesis in about 50% of the RA synovial samples.
Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
2) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.42 Pain Relevance 0.08
The researchers collected synovial tissue from 55 patients with rheumatoid arthritis and used two approaches, called immunohistochemistry and real-time PCR, to investigate whether FDC-containing structures in synovium expressed an enzyme called activation-induced cytidine deaminase (AID), which is needed for both somatic hypermutation and class-switch recombination.
Spec (whether) Gene_expression (expressed) of AID in synovium associated with rheumatoid arthritis
3) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.16
We next examined a) the direct functional relationship between the synovial expression of AID and CD21L and the production of ACPA and b) whether ectopic lymphoid aggregates within RA synovium maintain functionality independently from incoming immune cells from the periphery.
Gene_expression (expression) of AID in immune cells associated with rheumatoid arthritis
4) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.79 Pain Relevance 0.31
To evaluate whether the sustained expression of AID and CD21L mRNA in RA synovial grafts was associated with dynamic gene expression regulating ectopic lymphoneogenesis, we analysed mRNA expression levels of CXCL13, LT?
Gene_expression (expression) of AID associated with rheumatoid arthritis
5) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.50 Pain Relevance 0.29
A final and highly relevant observation obtained in the HuRA-SCID chimera is that the RA synovium, in the presence of follicular structures expressing AID and CD21L, behaves as a self-sustained microanatomical unit of ectopic lymphoid tissue.
Gene_expression (expressing) of AID in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
6) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.43 Pain Relevance 0.09
The researchers collected synovial tissue from 55 patients with rheumatoid arthritis and used two approaches, called immunohistochemistry and real-time PCR, to investigate whether FDC-containing structures in synovium expressed an enzyme called activation-induced cytidine deaminase (AID), which is needed for both somatic hypermutation and class-switch recombination.
Spec (whether) Gene_expression (expressed) of activation-induced cytidine deaminase in synovium associated with rheumatoid arthritis
7) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.16
Therefore, the main study objectives were to determine whether ectopic lymphoid structures in RA synovium: (i) express activation-induced cytidine deaminase (AID), the enzyme required for somatic hypermutation and class-switch recombination (CSR) of Ig genes; (ii) support ongoing CSR and ACPA production; and (iii) remain functional in a RA/severe combined immunodeficiency (SCID) chimera model devoid of new immune cell influx into the synovium.


Gene_expression (express) of activation-induced cytidine deaminase in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
8) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.95 Pain Relevance 0.30
Spearman's rank correlation was performed to correlate expression levels of AID and CD21L mRNA in RA synovial grafts.
Gene_expression (expression) of AID associated with rheumatoid arthritis
9) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.22 Pain Relevance 0.08
Finally, even low-level expression of AID and CD21L within the transplants was still associated with significant ACPA detection in the sera, while ACPA were barely detectable in the absence of AID mRNA expression in the RA grafts.
Gene_expression (expression) of AID mRNA associated with rheumatoid arthritis
10) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.23
Importantly, AID was detected only in the presence of CD21L in synovial grafts and AID mRNA expression levels closely correlated (r=0.88) with those of CD21L (Figure 5G).
Gene_expression (expression) of AID mRNA
11) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.79 Pain Relevance 0.33
Therefore, the main study objectives were to determine whether ectopic lymphoid structures in RA synovium: (i) express activation-induced cytidine deaminase (AID), the enzyme required for somatic hypermutation and class-switch recombination (CSR) of Ig genes; (ii) support ongoing CSR and ACPA production; and (iii) remain functional in a RA/severe combined immunodeficiency (SCID) chimera model devoid of new immune cell influx into the synovium.


Gene_expression (express) of AID in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
12) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.96 Pain Relevance 0.30
In particular, we have shown how AID 57 and 59 are well expressed at the protein level, while AID 50 is not, although its mRNA is abundant.
Gene_expression (expressed) of AID
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.44 Pain Relevance 0.04
In transgenic animals, most of AID is produced in the cell body, “far” from those neuronal compartments (axons/synapses) were this peptide might play its pathophysiological role.
Gene_expression (produced) of AID in synapses associated with targeted disruption
14) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.78 Pain Relevance 0.04
APP processing occurring in axonal extensions and/or synapses, leading to regional production of AID, may play a physiological role that, if disregulated, could lead to synaptic disfunction.
Gene_expression (production) of AID in synapses
15) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.72 Pain Relevance 0.04
To determine whether AID could trigger an AD-like neurodegenerative process in vivo, we have made transgenic mice expressing AID-peptides in the CNS [27].
Gene_expression (expressing) of AID associated with targeted disruption, neurodegenerative disease and disease
16) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.34 Pain Relevance 0
Here, we have further characterized our AID transgenic mice to determine whether over-expression of AID in the forebrain, when human Tau is also expressed, provokes AD-like features, as recently suggested [22].
Spec (whether) Gene_expression (over) of AID in forebrain associated with targeted disruption and disease
17) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.28 Pain Relevance 0.04
We have chosen this model as it shows progressive, age-related, Tau pathology in forebrain regions of the brain which are also affected in human AD pathology (hippocampus, parahippocampal cortex, frontal cortex etc.) and which overlap with the pattern of expression of the AID transgene, without necessarily expressing mutated Tau.


Gene_expression (expression) of AID transgene in brain associated with urological neuroanatomy, hippocampus and disease
18) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.05 Pain Relevance 0.05
AID overexpression in our model is very high, as determined by Real Time PCR, and as evident from WB analysis [27].
Gene_expression (overexpression) of AID
19) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.41 Pain Relevance 0.04
Both CSR and SHM are initiated by and critically dependent upon the expression of the enzyme activation-induced cytidine deaminase (AID) [17].
Gene_expression (expression) of AID
20) Confidence 0.62 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.13 Pain Relevance 0.04

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