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Context Info
Confidence 0.10
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cyth2) intracellular (Cyth2) cytoplasm (Cyth2)
Cyth2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 3 98.10 Very High Very High Very High
Enkephalin 4 97.22 Very High Very High Very High
MU agonist 2 90.56 High High
opioid receptor 2 87.12 High High
tolerance 1 83.84 Quite High
addiction 1 82.72 Quite High
opiate 3 82.00 Quite High
Opioid 1 75.00 Quite High
antagonist 1 68.84 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prediction based upon these observations is that, using [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin to label mu binding sites, chronic morphine should upregulate only the mu cx binding site, whereas chronic naltrexone should additionally up-regulate the mu ncx binding site.
Positive_regulation (up-regulate) of mu ncx binding site associated with enkephalin and morphine
1) Confidence 0.10 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2540993 Disease Relevance 0 Pain Relevance 1.15

General Comments

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