INT25835

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.47
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
platelet 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 99.98 Very High Very High Very High
Buprenorphine 1 98.40 Very High Very High Very High
Intracerebroventricular 1 97.72 Very High Very High Very High
aspirin 3 96.04 Very High Very High Very High
opiate 3 95.80 Very High Very High Very High
antagonist 1 85.84 High High
rheumatoid arthritis 1 79.72 Quite High
Inflammation 3 78.72 Quite High
MU agonist 2 76.88 Quite High
Morphine 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 1 98.88 Very High Very High Very High
Rheumatoid Arthritis 1 79.72 Quite High
INFLAMMATION 3 78.72 Quite High
Thrombosis 1 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A variety of data support the hypothesis of an opiate receptor complex composed of distinct, yet interacting mu and delta binding sites (termed mu cx and delta cx to indicate binding sites 'in the complex'), in addition to independent mu and delta binding sites, termed mu ncx and delta ncx, to indicate binding sites 'not in the complex'.
ncx Binding (termed) of associated with opiate
1) Confidence 0.36 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2540993 Disease Relevance 0 Pain Relevance 0.74
Intracerebroventricular administration of antisense DNA to the cloned delta receptor selectively decreased [3H][D-Ala2,D-Leu5]enkephalin binding to the delta ncx-1 site.
ncx-1 site Binding (binding) of associated with enkephalin and intracerebroventricular
2) Confidence 0.18 Published 1998 Journal Peptides Section Abstract Doc Link 9700759 Disease Relevance 0 Pain Relevance 0.64
In vitro studies have demonstrated the ability of NCX-4016 to interfere with platelet aggregation, adhesion and thromboxane B2 production.
NCX-4016 Binding (interfere) of in platelet associated with adhesions
3) Confidence 0.18 Published 1998 Journal IDrugs Section Abstract Doc Link 18465536 Disease Relevance 0.47 Pain Relevance 0.41

General Comments

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