INT25837

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Context Info
Confidence 0.10
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) nucleus (Dbp) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 1
Dbp (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 3 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
antagonist 1 98.94 Very High Very High Very High
Enkephalin 4 98.44 Very High Very High Very High
Morphine 3 89.04 High High
opioid receptor 2 76.64 Quite High
Opioid 1 75.00 Quite High
tolerance 1 29.84 Quite Low
addiction 1 28.72 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligand binding studies using membranes and slide-mounted sections of rat brain support the hypothesis that the irreversible mu-antagonist beta-funaltrexamine (FNA) selectively alkylates the opiate receptor complex, altering the binding of mu agonists to the mu cx binding site and the binding of [3H][D-Ala2,D-Leu5]enkephalin to the delta cx site.
mu cx binding site Binding (binding) of opiate receptor in brain associated with mu agonist, antagonist, enkephalin and opiate
1) Confidence 0.10 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2540993 Disease Relevance 0 Pain Relevance 1.05

General Comments

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