INT258447

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TYK2) cytoskeleton (TYK2) nucleus (TYK2)
cytoplasm (TYK2)
TYK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 78.56 Quite High
fibrosis 10 65.08 Quite High
depression 4 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 74.24 Quite High
Hepatitis C Virus Infection 182 71.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 44 68.84 Quite High
Fibrosis 4 65.08 Quite High
Cirrhosis 12 61.92 Quite High
Injury 2 59.72 Quite High
Infection 2 52.84 Quite High
Chronic Hepatitis 2 50.00 Quite Low
Toxicity 20 36.60 Quite Low
Hemolytic Anemia 2 19.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the receptor-associated Janus-activated kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) then, in turn, lead to activation of transcription proteins 1 and 2 (STAT 1 and STAT 2).
Positive_regulation (Activation) of Tyk2
1) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.63 Pain Relevance 0.10
Activation of the receptor-associated Janus-activated kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) then, in turn, lead to activation of transcription proteins 1 and 2 (STAT 1 and STAT 2).
Positive_regulation (Activation) of tyrosine kinase 2
2) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.63 Pain Relevance 0.10

General Comments

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