INT258473

Context Info Confidence 0.05 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.65 Pain Relevance 0.05

nucleoplasm (TOP2A) nuclear chromosome (TOP2A) aging (TOP2A) chromosome segregation (TOP2A) enzyme binding (TOP2A) DNA binding (TOP2A)

TOP2A (Homo sapiens)

Pain Link Frequency Relevance Heat Dysuria 3 50.84 pain flank 2 48.84 Paracetamol 2 9.20 Analgesic 1 5.84 Inflammatory response 2 5.00 Bioavailability 2 5.00 headache 2 5.00 fibrosis 1 5.00 Prostatitis 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Bacterial Respiratory Disease 6 97.32 Communicable Diseases 2 92.00 Poisoning 9 91.04 Pyelonephritis 52 86.48 Repression 3 86.32 Leukemia 18 84.60 Cystitis 7 82.96 Colon Cancer 1 77.20 Infection 24 71.96 Stress 4 63.48

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Event

Anatomy

Negation

Speculation

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Disease term

These latter compounds, which target the prokaryotic type II topoisomerases DNA gyrase and topoisomerase IV, represent the most active and broad-spectrum antibacterials currently in clinical use (127–129).

gyrase Binding (target) of associated with bacterial respiratory disease

1) Confidence 0.05 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.49 Pain Relevance 0

The S enantiomer of ofloxacin displays antibacterial activity that is approximately 2 orders of magnitude greater than that of the R enantiomer; this enhanced activity is due to greater binding to and saturation of the binding site on the DNA gyrase enzyme (Morrissey et al 1996).

DNA gyrase Binding (binding) of associated with bacterial respiratory disease

2) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621400 Disease Relevance 0.96 Pain Relevance 0.05

Wild-type cells were exposed to the antibiotic ciprofloxacin, which binds DNA gyrase, causing DSBs [30], and compared to untreated wild-type cells.

DNA gyrase Binding (binds) of

3) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2912397 Disease Relevance 0.20 Pain Relevance 0

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