INT258473
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
These latter compounds, which target the prokaryotic type II topoisomerases DNA gyrase and topoisomerase IV, represent the most active and broad-spectrum antibacterials currently in clinical use (127129). | |||||||||||||||
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The S enantiomer of ofloxacin displays antibacterial activity that is approximately 2 orders of magnitude greater than that of the R enantiomer; this enhanced activity is due to greater binding to and saturation of the binding site on the DNA gyrase enzyme (Morrissey et al 1996). | |||||||||||||||
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Wild-type cells were exposed to the antibiotic ciprofloxacin, which binds DNA gyrase, causing DSBs [30], and compared to untreated wild-type cells. | |||||||||||||||
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