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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP2A) nuclear chromosome (TOP2A) aging (TOP2A)
chromosome segregation (TOP2A) enzyme binding (TOP2A) DNA binding (TOP2A)
TOP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dysuria 3 50.84 Quite High
pain flank 2 48.84 Quite Low
Paracetamol 2 9.20 Low Low
Analgesic 1 5.84 Low Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Prostatitis 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 6 97.32 Very High Very High Very High
Communicable Diseases 2 92.00 High High
Poisoning 9 91.04 High High
Pyelonephritis 52 86.48 High High
Repression 3 86.32 High High
Leukemia 18 84.60 Quite High
Cystitis 7 82.96 Quite High
Colon Cancer 1 77.20 Quite High
Infection 24 71.96 Quite High
Stress 4 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These latter compounds, which target the prokaryotic type II topoisomerases DNA gyrase and topoisomerase IV, represent the most active and broad-spectrum antibacterials currently in clinical use (127–129).
gyrase Binding (target) of associated with bacterial respiratory disease
1) Confidence 0.05 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.49 Pain Relevance 0
The S enantiomer of ofloxacin displays antibacterial activity that is approximately 2 orders of magnitude greater than that of the R enantiomer; this enhanced activity is due to greater binding to and saturation of the binding site on the DNA gyrase enzyme (Morrissey et al 1996).
DNA gyrase Binding (binding) of associated with bacterial respiratory disease
2) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621400 Disease Relevance 0.96 Pain Relevance 0.05
Wild-type cells were exposed to the antibiotic ciprofloxacin, which binds DNA gyrase, causing DSBs [30], and compared to untreated wild-type cells.
DNA gyrase Binding (binds) of
3) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2912397 Disease Relevance 0.20 Pain Relevance 0

General Comments

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