INT258474

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.01
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
proximal 1


Pain Term Frequency Confidence Heat
Neurotransmitter 21 94.76 High High
addiction 9 63.44 Quite High
Inflammation 8 47.76 Quite Low
Onset of action 2 31.28 Quite Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Infection 294 100.00 Very High Very High Very High
Sprains And Strains 66 95.76 Very High Very High Very High
Calcification 3 85.20 High High
Rod Or Cone Dystrophy 3 53.68 Quite High
Night Blindness 27 50.36 Quite High
Clostridium Difficile Infection 6 50.00 Quite Low
Channelopathies 51 50.00 Quite Low
INFLAMMATION 8 47.76 Quite Low
Disease 94 35.12 Quite Low
Recurrence 64 24.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings [67, 27, 84] revealed inhibition of CDI as a novel modulatory concept that contributes to the fine-tuning of Cav1.4 gating to prevent inactivation and thus support tonic neurotransmitter release in sensory cells and normal visual function in humans.
Negative_regulation (inhibition) of CDI associated with neurotransmitter
1) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.10 Pain Relevance 0.05
This could explain the lack of CDI in the wild-type Cav1.4 channel.
Negative_regulation (lack) of CDI
2) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.09 Pain Relevance 0.03
Wahl-Schott and colleagues postulated binding of the distal C-terminus (termed ICDI, inhibitor of CDI, in their publication) to the EF hand motif in the proximal C-terminus, thereby, uncoupling the EF hand from the Ca2+ sensing apparatus.
Negative_regulation (inhibitor) of CDI in proximal
3) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0 Pain Relevance 0.05
This was in contrast to a prior study conducted at the same hospital from 1991 to 2003 in which vancomycin demonstrated the ability to decrease complications vs metronidazole for CDI (Pépin et al 2004; Pépin et al 2007).
Negative_regulation (decrease) of CDI associated with infection
4) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621401 Disease Relevance 0.78 Pain Relevance 0
Of note, the NAP1/027 strain exhibits increased resistance to the fluoroquinolone antibiotics and a cohort study of the epidemic at one Quebec hospital identified prior fluoroquinolone use as the antibiotics most highly correlated with the development of CDI (Pépin et al 2005b).
Negative_regulation (development) of CDI associated with sprains and strains and infection
5) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621401 Disease Relevance 1.04 Pain Relevance 0

General Comments

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