INT258548

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.05
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thyroid 2
macrophage 1
blood vessel 1
spike 1
band 1
Meta (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 27 100.00 Very High Very High Very High
metalloproteinase 15 100.00 Very High Very High Very High
Pyramidal cell 20 99.88 Very High Very High Very High
Glutamate receptor 2 99.64 Very High Very High Very High
long-term potentiation 8 94.72 High High
Inflammation 47 93.60 High High
Inflammatory response 8 90.92 High High
cytokine 16 85.96 High High
chemokine 5 84.56 Quite High
palliative 8 61.60 Quite High
Disease Link Frequency Relevance Heat
Rupture 2 99.32 Very High Very High Very High
Thyroid Neoplasm 322 98.82 Very High Very High Very High
Thrombosis 2 97.64 Very High Very High Very High
Infarction 1 96.44 Very High Very High Very High
Atherosclerosis 19 95.52 Very High Very High Very High
Cancer 256 95.24 Very High Very High Very High
INFLAMMATION 57 93.60 High High
Multiple Endocrine Neoplasia 8 93.16 High High
Obesity 10 93.12 High High
Hereditary Neoplastic Syndromes 2 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).
Positive_regulation (activation) of meta in thyroid associated with thyroid neoplasm and metalloproteinase
1) Confidence 0.67 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.32 Pain Relevance 0.05
Initiation of new blood vessel formation requires activation of matrix metalloproteinases (MMPs) leading to degradation of the basement membrane, sprouting of ECs, and regulation of pericyte attachment for vessel stabilization.
Positive_regulation (activation) of meta in blood vessel associated with metalloproteinase
2) Confidence 0.67 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.40 Pain Relevance 0.23
More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).
Positive_regulation (activation) of meta in thyroid associated with thyroid neoplasm and metalloproteinase
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.89 Pain Relevance 0.23
Eventually, the plaque ruptures due to degradation by macrophage-induced matrix metalloproteinases (MMPs) and hydrolytic enzymes, resulting in thrombus formation and tissue infarction [22].
Positive_regulation (induced) of meta in macrophage associated with rupture, metalloproteinase, infarction and thrombosis
4) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.39 Pain Relevance 0.48
In layer 5 neocortical pyramidal neurons, the activation of type 5 metabotropic glutamate receptors (mGluR5) leads to a long-lasting reduction of the apamin-sensitive IAHP and the mAHP, resulting in the LTP of intrinsic excitability and increased spike timing precision [93].
Positive_regulation (activation) of meta in spike associated with glutamate receptor, pyramidal cell and long-term potentiation
5) Confidence 0.45 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.05 Pain Relevance 0.17
The pH-dependence of Meta I/Meta II,15 which reflects the proton uptake of rhodopsin during its transition to Meta II and is one of the hallmarks of activation of rhodopsin, is absent from E113Qstab.
Positive_regulation (dependence) of Meta associated with addiction
6) Confidence 0.20 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.14
Lack of the Glu113 counterion alters the Meta II precursor state of E113Qstab
Positive_regulation (state) of Meta
7) Confidence 0.20 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.12
As a consistent model, we propose in Meta II an orientation of the 15-anti Schiff base toward the cytoplasmic side of the receptor, away from Glu181, resulting in a low apparent pKA, while the 15-syn Schiff base in active Meta III is oriented toward Glu181, thereby increasing the apparent pKA considerably.
Positive_regulation (active) of Meta
8) Confidence 0.20 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
This proton transfer hypothesis was not compatible with Fourier transform infrared (FTIR) spectroscopic data,27 and instead a gradual shift of the counterion function from Glu113 to Glu181 on the activation pathway was found, with Glu181 remaining charged during the entire activation process and Glu113 becoming neutralized by proton transfer from the PSB only in the final transition to active Meta II.11
Positive_regulation (active) of Meta
9) Confidence 0.18 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
The amide I marker band of Meta I at 1663 cm? 
Positive_regulation (band) of Meta in band
10) Confidence 0.18 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0

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