INT258549

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thyroid 4
Meta (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 100.00 Very High Very High Very High
addiction 5 84.88 Quite High
palliative 8 62.92 Quite High
Glutamate 3 52.32 Quite High
agonist 3 5.00 Very Low Very Low Very Low
Sicca syndrome 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 322 99.64 Very High Very High Very High
Multiple Endocrine Neoplasia 8 95.88 Very High Very High Very High
Hereditary Neoplastic Syndromes 2 95.28 Very High Very High Very High
Cancer 108 91.12 High High
Carcinoma 46 86.88 High High
Chromosome Inversion 2 84.52 Quite High
Non-small-cell Lung Cancer 2 56.00 Quite High
Small Cell Lung Cancer 4 55.72 Quite High
Metastasis 30 49.20 Quite Low
Malignant Neoplastic Disease 8 34.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of meta in thyroid associated with thyroid neoplasm and metalloproteinase
1) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.90 Pain Relevance 0.24
Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of meta in thyroid associated with thyroid neoplasm and metalloproteinase
2) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.41 Pain Relevance 0.05
Lack of the Glu113 counterion alters the Meta II precursor state of E113Qstab
Regulation (alters) of Positive_regulation (state) of Meta
3) Confidence 0.18 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.12

General Comments

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