INT258581

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rap) intracellular (Il1rap) protein binding, bridging (Il1rap)
protein complex (Il1rap) signal transducer activity (Il1rap)
Anatomy Link Frequency
neurons 1
peripheral nerve 1
Il1rap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 13 98.32 Very High Very High Very High
c fibre 1 97.92 Very High Very High Very High
Pain 11 96.92 Very High Very High Very High
cytokine 39 95.80 Very High Very High Very High
Peripheral nerve injury 5 95.40 Very High Very High Very High
Lasting pain 3 93.52 High High
Hyperalgesia 2 90.84 High High
Inflammation 14 90.24 High High
Glutamate 2 87.12 High High
Neuropathic pain 58 84.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 100.00 Very High Very High Very High
Neuropathic Pain 91 98.88 Very High Very High Very High
Pain 14 96.92 Very High Very High Very High
Nervous System Injury 12 94.96 High High
Hyperalgesia 2 90.84 High High
INFLAMMATION 17 90.24 High High
Hypoxia 10 77.24 Quite High
Injury 13 70.84 Quite High
Hypersensitivity 1 64.56 Quite High
Diabetes Mellitus 1 59.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and therefore vagal axons may express the IL-1 receptor.
Gene_expression (express) of IL-1 receptor
1) Confidence 0.14 Published 2010 Journal Respiratory Physiology & Neurobiology Section Body Doc Link PMC2958315 Disease Relevance 0.46 Pain Relevance 0.35
Moreover, deletion of IL-1 receptor type 1 or transgenic overexpression of the naturally occurring IL-1 receptor antagonist (IL-1RA) delay the onset and severity of pain associated with peripheral nerve injury [10].
Gene_expression (overexpression) of IL-1 receptor type 1 in peripheral nerve associated with targeted disruption, pain, nervous system injury, antagonist and peripheral nerve injury
2) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2625335 Disease Relevance 1.72 Pain Relevance 1.26
is selectively localized to astrocytes, while IL-1 receptor (IL-1R) is exclusively expressed on neurons [12,48].
Gene_expression (expressed) of IL-1 receptor in neurons
3) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.40 Pain Relevance 0.82

General Comments

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