INT258584

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA3, ADCY1) plasma membrane (ADORA3, ADCY1) small molecule metabolic process (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
ADORA3 (Homo sapiens)
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 87 99.96 Very High Very High Very High
Potency 14 78.32 Quite High
adenocard 16 50.00 Quite Low
antagonist 19 42.12 Quite Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Chronic Renal Failure 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Hypercalcemia 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Reprotox - General 2 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously described that our cyclic AMP functional assay system is an ideal model for the characterization of the functional aspects of this class of allosteric modulators, especially the characterization of their effects on maximal agonist efficacy due to the less-than-complete inhibition of adenylyl cyclase by A3 AR agonists [16,17].
A3 AR Negative_regulation (inhibition) of adenylyl cyclase associated with agonist
1) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.44

General Comments

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