INT2586

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 9.25
Pain Relevance 11.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
plasma 9
alpha cells 1
liver 1
pancreas 1
beta cells 1
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 12 100.00 Very High Very High Very High
anesthesia 25 99.98 Very High Very High Very High
Somatostatin 42 99.88 Very High Very High Very High
tetrodotoxin 4 99.88 Very High Very High Very High
Opioid 17 99.84 Very High Very High Very High
Catecholamine 6 99.80 Very High Very High Very High
noradrenaline 14 99.68 Very High Very High Very High
antagonist 13 99.58 Very High Very High Very High
opiate 9 99.54 Very High Very High Very High
Bile 3 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 4 99.84 Very High Very High Very High
Aging 12 99.76 Very High Very High Very High
Injury 43 99.72 Very High Very High Very High
Iron Overload 3 99.40 Very High Very High Very High
Appetite Loss 13 99.20 Very High Very High Very High
Stress 12 98.76 Very High Very High Very High
Impaired Glucose Tolerance 9 98.58 Very High Very High Very High
Diabetes Mellitus 25 98.12 Very High Very High Very High
Cancer 82 96.68 Very High Very High Very High
Sprains And Strains 1 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that pancreatic glucagon is not elevated in the PV-stenosed rat; differences between these results and those describing hyperglucagonemia in this model cannot be explained on the basis of a differential response to stress but may reflect differences in glucagon assay system.
Neg (not) Positive_regulation (elevated) of glucagon associated with stress
1) Confidence 0.70 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648985 Disease Relevance 0.88 Pain Relevance 0.25
At 20 mmol/l glucose plus 10(-8) mol/l glucagon, these fractional release rates increased by 16 and 40-fold respectively.
Positive_regulation (increased) of glucagon
2) Confidence 0.67 Published 1990 Journal Diabetologia Section Abstract Doc Link 2076797 Disease Relevance 0 Pain Relevance 0.08
When morphine was combined with somatostatin, the increase in glucose, insulin and glucagon was significantly reduced.
Positive_regulation (increase) of glucagon associated with somatostatin and morphine
3) Confidence 0.60 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0 Pain Relevance 1.07
However, after the morphine and propranolol stimulation the increase in glucose and glucagon was significantly reduced, whereas the insulin levels were as high as when morphine was given alone.
Positive_regulation (increase) of glucagon associated with morphine
4) Confidence 0.60 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0 Pain Relevance 1.09
Although ether anesthesia increases circulating glucagon levels in the porta and cava veins, the qualitative changes of plasma insulin and glucagon in Pn and Pn + Mel were similar to those found in conscious rats.
Positive_regulation (increases) of glucagon in veins associated with anesthesia
5) Confidence 0.60 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3519410 Disease Relevance 0.06 Pain Relevance 0.10
It is evident from elevated levels of ACTH, hydrocortisone, leuenkephaline, glucagon and gastrin.
Positive_regulation (elevated) of glucagon
6) Confidence 0.60 Published 1991 Journal Vopr Kurortol Fizioter Lech Fiz Kult Section Abstract Doc Link 1838221 Disease Relevance 0.10 Pain Relevance 0.08
Although any linear correlation was not demonstrated between aging and blood glucose, plasma insulin or glucagon levels, post-glucose levels of blood glucose were significantly suppressed and those of plasma glucagon were significantly elevated at 4 to 6 months of age.
Positive_regulation (elevated) of glucagon in plasma associated with aging
7) Confidence 0.60 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477620 Disease Relevance 0.46 Pain Relevance 0.16
Portal and aortic glucagon levels increased in the NA-infused CA and HA, but no changes were observed in the NA-infused WC.
Positive_regulation (increased) of glucagon associated with noradrenaline
8) Confidence 0.56 Published 1983 Journal Jpn. J. Physiol. Section Abstract Doc Link 6366308 Disease Relevance 0 Pain Relevance 0.64
Then, one of the possible mechanisms for the hyperglycemic response after morphine may be an opioid effect on pancreas, stimulating glucagon and thereby causing hepatic glucose output.
Positive_regulation (stimulating) of glucagon in pancreas associated with opioid and morphine
9) Confidence 0.56 Published 1992 Journal Life Sci. Section Abstract Doc Link 1528092 Disease Relevance 0.07 Pain Relevance 0.94
SS antagonist administration also increased plasma glucagon, insulin, and glucose levels.
Positive_regulation (increased) of glucagon in plasma associated with antagonist and somatostatin
10) Confidence 0.49 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.79
The enhanced glucagon response to arginine and the nonsuppressibility of glucagon secretion by oral glucose found in these patients were similar to the results found in the same tests performed in our previous series of patients with "idiopathic" diabetes and at variance with those reported by others in patients with chronic pancreatitis.
Positive_regulation (response) of glucagon associated with diabetes mellitus and chronic pancreatitis
11) Confidence 0.49 Published 1977 Journal Diabetologia Section Abstract Doc Link 908475 Disease Relevance 0.80 Pain Relevance 0.09
Insulin produced a significant increase in glucagon levels, and GLP-1 analog produced a significant increase in insulin levels without any change in other glucoregulatory and stress hormone levels.
Positive_regulation (increase) of glucagon associated with stress
12) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16280413 Disease Relevance 0.97 Pain Relevance 0.18
It is concluded from the present data that glucose tolerance does not apparently deteriorate during aging process in rats but that glucagon responses to oral glucose administration are elevated with aging.
Positive_regulation (elevated) of glucagon associated with aging, tolerance and impaired glucose tolerance
13) Confidence 0.46 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477620 Disease Relevance 0.74 Pain Relevance 0.18
The significance of glucagon and of the sympatho-adrenal system for insulin secretion and hepatic glycogen depletion during exercise was studied.
Positive_regulation (significance) of glucagon
14) Confidence 0.43 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7021387 Disease Relevance 0.05 Pain Relevance 0.08
Significance of glucagon for insulin secretion and hepatic glycogenolysis during exercise in rats.
Positive_regulation (Significance) of glucagon
15) Confidence 0.43 Published 1981 Journal Horm. Metab. Res. Section Title Doc Link 7021387 Disease Relevance 0.07 Pain Relevance 0.09
Increments in glucose, glucagon and insulin after morphine in rats, and naloxone blocking of this effect.
Positive_regulation (Increments) of glucagon associated with narcan and morphine
16) Confidence 0.41 Published 1992 Journal Life Sci. Section Title Doc Link 1528092 Disease Relevance 0.09 Pain Relevance 0.91
Insulin levels increased sharply after glucagon, from 381 +/- 78 pmol/l to 3172 +/- 668 pmol/l at 15 min, and plateaued at approximately 1000 pmol/l thereafter.
Positive_regulation (increased) of glucagon
17) Confidence 0.40 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7798030 Disease Relevance 0.13 Pain Relevance 0.03
Procaine treatment increased the glucagon and fluoride activation of the cyclase and the stimulation was concentration-dependent; this compound seemed to act at the G/F unit level since changes in the glucagon binding were not observed and the basal activity was not modified.
Positive_regulation (activation) of glucagon
18) Confidence 0.40 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6309252 Disease Relevance 0 Pain Relevance 0.09
Cutaneous pinching for 3.5 min of the face, forepaw, abdomen, or hindpaw increased the plasma immunoreactive glucagon (IRG), and the increase was larger following pinching of the abdmen or hindpaw than pinching of the face or forepaw.
Positive_regulation (increased) of glucagon in plasma
19) Confidence 0.39 Published 1994 Journal Jpn. J. Physiol. Section Abstract Doc Link 7823413 Disease Relevance 0.05 Pain Relevance 0
In contrast, the opiate peptide significantly stimulated plasma glucagon and decreased plasma glucose, both 10 and 30 min following injection.
Positive_regulation (stimulated) of glucagon in plasma associated with opiate
20) Confidence 0.39 Published 1983 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6141770 Disease Relevance 0 Pain Relevance 0.36

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