INT25864

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.46
Pain Relevance 2.47

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mitochondrion (Nme4) structural constituent of ribosome (Nme4) oxidoreductase activity (Nme4)
ribosome (Nme4) intracellular (Nme4) translation (Nme4)
Anatomy Link Frequency
Acb 1
striatum 1
Nme4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Nucleus accumbens 7 99.76 Very High Very High Very High
Morphine 8 99.62 Very High Very High Very High
depression 1 97.72 Very High Very High Very High
opiate 8 96.48 Very High Very High Very High
MU agonist 2 92.00 High High
Opioid 4 83.52 Quite High
Clonidine 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 1 99.72 Very High Very High Very High
Catalepsy 1 97.80 Very High Very High Very High
Depression 1 97.72 Very High Very High Very High
Hyperphagia 1 92.20 High High
Attention Deficit Hyperactivity Disorder 2 73.44 Quite High
Injury 2 50.00 Quite Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intrathecal injection of [D-Ala2, NMePhe4, Gly-ol]enkephalin (DAMGO) produced A50 values of 0.23 microgram (range, 0.09-0.6) and 0.97 microgram (range, 0.34-2.7) in sham-operated and ligated rats, respectively.
Gene_expression (produced) of NMePhe4
1) Confidence 0.40 Published 1997 Journal Anesthesiology Section Body Doc Link 9009955 Disease Relevance 0 Pain Relevance 0
High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt sedation in all the age groups and also induced catalepsy which was particularly apparent in the 5- and 10-day-old animals.
Gene_expression (produced) of NMe-Phe4 associated with catalepsy, enkephalin, sleep disorders and morphine
2) Confidence 0.16 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2541460 Disease Relevance 0.37 Pain Relevance 0.56
Morphine (0, 0.5, 5 micrograms/0.5 microliter), the mu agonist D-Ala2, NMe-Phe4, Glyo 15-enkephalin (DAMGO; 0, 0.025, 0.25 and 2.5 micrograms/0.5 microliter), the delta agonist D-Pen2,5-enkephalin (DPEN; 0, 0.031, 0.31, 3.1 micrograms/0.5 microliter), and the kappa agonists U50488H (0, 0.0186, 0.186, 1.86 micrograms/0.5 microliter), and dynorphin (0, 0.05, 0.5, 5 micrograms/0.5 microliter) were microinfused into Acb.
Gene_expression (microinfused) of NMe-Phe4 in Acb associated with nucleus accumbens, dynorphin, agonist, enkephalin and morphine
3) Confidence 0.12 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9298512 Disease Relevance 0 Pain Relevance 1.33
Equimolar doses of the synthetic ligands [D-Ala2,NME-Phe4,Gly-ol5]-enkephalin (DAMGO; 0, 0.025, 0.25, and 2.5 micrograms/0.5 microliter), [D-Pen2,5]-enkephalin (DPEN; 0, 0.031, 0.31, 3.1 and 6.2 micrograms/0.5 microliter) and U50,488H (0, 0.0186, 0.186, 1.86 and 3.72 micrograms/0.5 microliters), which are selective for mu, delta and kappa receptors, respectively, were microinfused into three striatal sites: the nucleus accumbens, ventromedial striatum and ventrolateral striatum.
Gene_expression (selective) of NME-Phe4 in striatum associated with nucleus accumbens and enkephalin
4) Confidence 0.10 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8389860 Disease Relevance 0.09 Pain Relevance 0.58

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