INT258685

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 2
neurite 2
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 36 98.64 Very High Very High Very High
Inflammation 43 94.80 High High
Neurobehavioral 1 52.36 Quite High
Neurotransmitter 6 45.16 Quite Low
monoamine 3 44.48 Quite Low
Dopamine 4 38.60 Quite Low
Inflammatory response 14 37.76 Quite Low
Serotonin 2 28.60 Quite Low
cytokine 9 20.44 Low Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 97.48 Very High Very High Very High
Targeted Disruption 18 95.48 Very High Very High Very High
INFLAMMATION 60 94.80 High High
Cancer 2 93.68 High High
Cognitive Disorder 13 91.00 High High
Leukemia 1 88.32 High High
Breast Cancer 1 85.92 High High
Ovarian Cancer 1 84.48 Quite High
Frontotemporal Dementia 8 67.92 Quite High
Poisoning 4 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was due to dose-dependent changes in expression at 6 h for several genes that control neurite branching and morphogenesis including Cxcl12, Notch1 and ?
Regulation (changes) of Gene_expression (morphogenesis) of Notch1 in neurite
1) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.05 Pain Relevance 0.03
Notably, targeting the Notch pathway by using ?
Regulation (targeting) of Gene_expression (pathway) of Notch in Notch
2) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.40 Pain Relevance 0.27

General Comments

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