INT2587

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Context Info
Confidence 0.60
First Reported 1979
Last Reported 2005
Negated 5
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 1.73
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
pancreas 12
spinal 2
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 37 100.00 Very High Very High Very High
Clonidine 26 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Morphine 17 99.98 Very High Very High Very High
aspirin 9 99.42 Very High Very High Very High
tolerance 3 99.26 Very High Very High Very High
antagonist 15 98.64 Very High Very High Very High
agonist 22 98.60 Very High Very High Very High
qutenza 3 92.36 High High
anesthesia 4 86.60 High High
Disease Link Frequency Relevance Heat
Aging 6 99.68 Very High Very High Very High
Impaired Glucose Tolerance 3 99.26 Very High Very High Very High
Nociception 1 98.82 Very High Very High Very High
Diabetes Mellitus 14 98.68 Very High Very High Very High
Hypoglycemia 4 97.84 Very High Very High Very High
Hyperinsulinism 1 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that excitation of cutaneous nociceptive afferent information from the various spinal segments can regulate glucagon secretion from the pancreas as a reflex response, whose efferent limb is dually composed of both sympathetic and parasympathetic nerves.
Regulation (regulate) of Localization (secretion) of glucagon in spinal associated with nociception
1) Confidence 0.60 Published 1994 Journal Jpn. J. Physiol. Section Abstract Doc Link 7823413 Disease Relevance 0.10 Pain Relevance 0
Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.
Regulation (Effects) of Localization (secretion) of glucagon in pancreas associated with agonist and clonidine
2) Confidence 0.55 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.42
Also, both 100 mumol/l acetylsalicylic acid (cyclooxygenase inhibitor) and 100 mumol/l caffeic acid (lipoxygenase inhibitor) significantly inhibited clonidine-induced glucagon secretion (P less than 0.01, respectively), whereas neither 10 mumol/l acetylsalicylic acid nor 10 mumol/l caffeic acid affected clonidine-induced glucagon secretion.
Neg (nor) Regulation (affected) of Localization (secretion) of glucagon associated with aspirin and clonidine
3) Confidence 0.55 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
The phospholipase A2 inhibitor mepacrine at 25 and 50 mumol/l significantly inhibited glucagon secretion induced by 0.1 mumol/l clonidine (P less than 0.01, respectively), whereas 5 mumol/l mepacrine did not affect clonidine-induced glucagon secretion.
Neg (not) Regulation (affect) of Localization (secretion) of glucagon associated with clonidine
4) Confidence 0.55 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.59
This shows that morphine induces the release of insulin, glucagon and somatostatin from pancreas in a dose-dependent way, and that release of insulin and glucagon is not primarily affected by regulation of somatostatin levels.
Neg (not) Regulation (affected) of Localization (release) of glucagon in pancreas associated with somatostatin and morphine
5) Confidence 0.50 Published 1994 Journal Res Exp Med (Berl) Section Abstract Doc Link 7800932 Disease Relevance 0 Pain Relevance 0.65
Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures.
Regulation (Control) of Localization (secretion) of glucagon
6) Confidence 0.48 Published 1988 Journal Endocrinology Section Title Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.05
Effects of alpha 2- and beta-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats.
Regulation (Effects) of Localization (secretion) of glucagon associated with diabetes mellitus
7) Confidence 0.48 Published 1993 Journal Metab. Clin. Exp. Section Title Doc Link 8102194 Disease Relevance 0.18 Pain Relevance 0.20
In contrast, adrenergic regulation of glucagon secretion remains controversial.
Regulation (regulation) of Localization (secretion) of glucagon
8) Confidence 0.48 Published 1993 Journal Metab. Clin. Exp. Section Abstract Doc Link 8102194 Disease Relevance 0.16 Pain Relevance 0.15
Furthermore, comparisons of various kinds of indices among the different age groups, such as insulinogenic index, insulin/glucagon and so forth during oral glucose tolerance tests also indicate the significant alteration of glucagon secretion during aging process.
Regulation (alteration) of Localization (secretion) of glucagon associated with aging, tolerance and impaired glucose tolerance
9) Confidence 0.45 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477620 Disease Relevance 0.66 Pain Relevance 0.19
Non-adrenergic non-cholinergic effects do not participate in regulation of glucagon and somatostatin secretion under the conditions employed.
Regulation (regulation) of Localization (secretion) of glucagon associated with somatostatin
10) Confidence 0.44 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0 Pain Relevance 0.31
Morphine effects on the release of glucagon, insulin and somatostatin from the isolated, perfused rat pancreas.
Regulation (effects) of Localization (release) of glucagon in pancreas associated with somatostatin and morphine
11) Confidence 0.37 Published 1994 Journal Res Exp Med (Berl) Section Title Doc Link 7800932 Disease Relevance 0 Pain Relevance 0.62
This shows that morphine induces the release of insulin, glucagon and somatostatin from pancreas in a dose-dependent way, and that release of insulin and glucagon is not primarily affected by regulation of somatostatin levels.
Neg (not) Regulation (affected) of Localization (release) of glucagon in pancreas associated with somatostatin and morphine
12) Confidence 0.37 Published 1994 Journal Res Exp Med (Berl) Section Abstract Doc Link 7800932 Disease Relevance 0 Pain Relevance 0.67
Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release.
Regulation (Effects) of Localization (release) of glucagon associated with somatostatin
13) Confidence 0.36 Published 1987 Journal Life Sci. Section Title Doc Link 2886886 Disease Relevance 0 Pain Relevance 0.39
The stimulatory action of glucose in isolated alpha-cells contrasts with the suppressive effect of the sugar in intact islets and highlights the primary importance of islet paracrine signaling in the regulation of glucagon release.
Regulation (regulation) of Localization (release) of glucagon
14) Confidence 0.35 Published 2005 Journal Endocrinology Section Abstract Doc Link 16081632 Disease Relevance 0 Pain Relevance 0.06
In contrast, neither of the two alpha-1 selective agonists, methoxamine and phenylephrine, at concentrations up to 10(-6) mol/l affected glucagon release.
Neg (neither) Regulation (affected) of Localization (release) of glucagon associated with agonist
15) Confidence 0.32 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1357904 Disease Relevance 0 Pain Relevance 0.53
Effect of electrical field stimulation on insulin and glucagon secretion from the pancreas of normal and diabetic rats.
Regulation (Effect) of Localization (secretion) of glucagon in pancreas associated with diabetes mellitus
16) Confidence 0.27 Published 2001 Journal Horm. Metab. Res. Section Title Doc Link 11440274 Disease Relevance 0.46 Pain Relevance 0.26
It is concluded that the alpha 2 receptor mechanism plays the most important role in the adrenergic modulation of glucagon secretion in rats under physiological conditions.
Regulation (modulation) of Localization (secretion) of glucagon
17) Confidence 0.27 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.26
The present study was designed to clarify the mechanism of adrenergic modulation of pancreatic glucagon secretion in rats under physiological conditions by 1) epinephrine infusion alone or together with adrenergic blockers and 2) administration of adrenergic agonists.
Regulation (modulation) of Localization (secretion) of glucagon associated with agonist
18) Confidence 0.27 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.16
Alpha 2-adrenergic modulation of pancreatic glucagon secretion in rats.
Regulation (modulation) of Localization (secretion) of glucagon
19) Confidence 0.27 Published 1992 Journal Physiol. Behav. Section Title Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.22
The effect of analog RC-160 on glucagon release was studied in rats with glucagon levels elevated by hypoglycemia.
Regulation (effect) of Localization (release) of glucagon associated with hypoglycemia
20) Confidence 0.27 Published 1987 Journal Life Sci. Section Abstract Doc Link 2886886 Disease Relevance 0.18 Pain Relevance 0.33

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