INT258710

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
thyroid 2
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 51 100.00 Very High Very High Very High
monoamine 3 97.24 Very High Very High Very High
Neurotransmitter 6 96.68 Very High Very High Very High
Serotonin 2 88.64 High High
Neurobehavioral 1 78.88 Quite High
Substantia nigra 9 62.16 Quite High
midbrain 1 14.52 Low Low
Opioid receptor 1 7 5.00 Very Low Very Low Very Low
bDMF 5 5.00 Very Low Very Low Very Low
hyperexcitability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Disease 21 95.76 Very High Very High Very High
Dyskinesias 34 94.52 High High
Tremor 2 89.72 High High
Hyperthyroidism 2 87.44 High High
Hyperkinesis 5 85.88 High High
Thyroid Disease 2 80.68 Quite High
Poisoning 4 76.88 Quite High
Stress 1 67.72 Quite High
Parkinson's Disease 6 50.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism controlling Ddc mRNA repression following pyrethroid exposure is unclear, but provides support that monoaminergic neurotransmitter systems are sensitive to the compounds.
Regulation (controlling) of Negative_regulation (repression) of Ddc associated with neurotransmitter, repression and monoamine
1) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.24 Pain Relevance 0.49
To determine the neural basis for these effects of TRH and thyroid hormones, we examined the effects of dopamine depletion and subsequent L-DOPA treatment on the striatal expression of preproTRH mRNA by quantitative PCR (qPCR) and proTRH peptide by immunohistochemistry and by radioimmunoassay (RIA) [10], [20], [21].
Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (depletion) of L-DOPA in thyroid associated with dopamine
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 1.03 Pain Relevance 0.18

General Comments

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