INT25872

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 4.90
Pain Relevance 15.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
Spinal 2
peripheral nerve 1
striatum 1
lungs 1
nociceptor 1
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 149 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
depression 27 99.92 Very High Very High Very High
Peripheral nerve injury 10 99.74 Very High Very High Very High
Dorsal horn 1 99.64 Very High Very High Very High
gABA 47 99.44 Very High Very High Very High
tolerance 225 99.36 Very High Very High Very High
allodynia 17 99.14 Very High Very High Very High
Dopamine 43 99.04 Very High Very High Very High
antinociception 14 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 6 100.00 Very High Very High Very High
Depression 27 99.92 Very High Very High Very High
Nervous System Injury 10 99.74 Very High Very High Very High
Neuropathic Pain 22 99.14 Very High Very High Very High
Hypoxia 25 98.98 Very High Very High Very High
Pain 6 98.64 Very High Very High Very High
Cv General 4 Under Development 12 98.48 Very High Very High Very High
Sleep Disorders 29 95.20 Very High Very High Very High
Repression 1 93.84 High High
Hyperalgesia 12 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both antinociception and locomotor stimulation appear to be dependent on activation of adenosine A1 receptors, as effects of 3,7-dimethyl-1-propargylxanthine are observed only at a dose which blocks adenosine A1 receptors in addition to A2 receptors.
Positive_regulation (activation) of adenosine A1 associated with antinociception and adenocard
1) Confidence 0.69 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8867096 Disease Relevance 0 Pain Relevance 0.56
In conclusion, our results showed that infusion of adenosine significantly elevated the sensitivity of pulmonary C-fiber afferents in rat lungs and that this potentiating effect is likely mediated through activation of the adenosine A1 receptor.
Positive_regulation (activation) of adenosine A1 receptor in lungs associated with c fibre and adenocard
2) Confidence 0.66 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12754169 Disease Relevance 0.07 Pain Relevance 0.66
Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
Positive_regulation (activation) of A1 adenosine receptor in spinal associated with adenocard, nervous system injury, allodynia, peripheral nerve injury, morphine and intrathecal
3) Confidence 0.61 Published 2005 Journal Anesthesiology Section Title Doc Link 15681960 Disease Relevance 0.48 Pain Relevance 1.24
Here we tested in vivo whether synaptic depression by adenosine A1 receptor (A1R) activation contributes to BS patterns following GCI.
Spec (whether) Positive_regulation (activation) of adenosine A1 receptor associated with adenocard, depression and ischemia
4) Confidence 0.55 Published 2009 Journal Neuroscience Section Abstract Doc Link 19344634 Disease Relevance 0.72 Pain Relevance 0.56
Despite previous studies demonstrating that morphine releases less adenosine after peripheral nerve injury, the current study suggests that the antihypersensitivity effect of morphine in these conditions is totally reliant on A1 adenosine receptor activation.


Positive_regulation (activation) of A1 adenosine receptor in peripheral nerve
5) Confidence 0.50 Published 2005 Journal Anesthesiology Section Body Doc Link 15681960 Disease Relevance 0 Pain Relevance 0
From these results, it is suggested that acute hypoxia depresses the excitatory synaptic transmission by activating the presynaptic adenosine A1 receptor.
Positive_regulation (activating) of adenosine A1 receptor associated with adenocard and hypoxia
6) Confidence 0.45 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12127984 Disease Relevance 0.79 Pain Relevance 0.53
BACKGROUND: A1 adenosine receptor activation reduces hypersensitivity in animal models of chronic pain, but intrathecal adenosine does not produce analgesia to acute noxious stimuli.
Positive_regulation (activation) of A1 adenosine receptor associated with adenocard, lasting pain, hypersensitivity, analgesia and intrathecal
7) Confidence 0.39 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249681 Disease Relevance 0.20 Pain Relevance 0.50
These results lead to conclusions that FRTL-5 cells lack alpha 2-adrenergic receptor but have beta-adrenergic receptor which lacks coupling with adenylate cyclase and have adenosine A1 receptor, and that the adrenergic receptors and adenosine A1 receptor are not the site of action of anti-fucosyl GM1 antibody.
Positive_regulation (have) of A1 receptor in FRTL-5 associated with adenocard
8) Confidence 0.38 Published 1989 Journal Endocrinology Section Abstract Doc Link 2541996 Disease Relevance 0 Pain Relevance 0.29
These results indicate that adenosine elicits a respiratory inhibition via stimulation of pulmonary C fibers and that activation of the A1-receptor is probably involved.
Positive_regulation (activation) of A1-receptor in respiratory associated with adenocard
9) Confidence 0.35 Published 1998 Journal J. Appl. Physiol. Section Abstract Doc Link 9475846 Disease Relevance 0.38 Pain Relevance 0.60
This study demonstrates a peripheral antinociceptive action mediated by endogenous adenosine which accumulates following the peripheral inhibition of adenosine kinase; this action is due to activation of an adenosine A1 receptor.
Positive_regulation (activation) of adenosine A1 receptor associated with adenocard and antinociceptive
10) Confidence 0.33 Published 1998 Journal Pain Section Abstract Doc Link 9514563 Disease Relevance 0 Pain Relevance 0.82
Spinal adenosine A1 receptor activation induced dorsal horn norepinephrine release, ultimately leading to analgesia by an ?
Positive_regulation (activation) of adenosine A1 receptor in Spinal associated with adenocard, dorsal horn and analgesia
11) Confidence 0.27 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908226 Disease Relevance 0.59 Pain Relevance 1.63
CONCLUSION: ICV and IT administration of adenosine agonist R-PIA produced an antinociceptive effect in a dose-dependent manner and decreased halothane MAC with painful stimulation through activation of A1 receptor subtype, and the underlying mechanism involves K+ channel activation.


Positive_regulation (activation) of A1 receptor
12) Confidence 0.21 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15663896 Disease Relevance 0 Pain Relevance 0
2, JunD (Jun D proto-oncogene) and Adenosine A1 receptor, which were up-regulated, and GZMA (Granzyme A) and IFN?
Positive_regulation (up-regulated) of Adenosine A1 receptor associated with adenocard
13) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0.59 Pain Relevance 0.62
Effects of adenosine A1 and A2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices.
Positive_regulation (activation) of adenosine A1 associated with dopamine and adenocard
14) Confidence 0.19 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7902434 Disease Relevance 0 Pain Relevance 0.65
The authors investigated how electrically evoked [3H]dopamine (DA) and [14C]acetylcholine (ACh) release in the rat striatum is affected, directly or indirectly, by adenosine A1 and A2A receptor activation.
Positive_regulation (activation) of adenosine A1 in striatum associated with adenocard and dopamine
15) Confidence 0.17 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7902434 Disease Relevance 0 Pain Relevance 0.44
These cross-dependence and cross-withdrawal responses suggest that the development of dependence to mu-opioid and A1-adenosine agonists involves changes in the same second messenger system downstream to both mu-opioid and A1-adenosine receptor activation.
Positive_regulation (activation) of A1-adenosine associated with addiction, adenocard, agonist, opioid and withdrawal
16) Confidence 0.10 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613740 Disease Relevance 0.33 Pain Relevance 1.98
Opening of KATP channels is thought to relate to adenosine A1 receptor activation.
Positive_regulation (activation) of adenosine A1 receptor associated with adenocard
17) Confidence 0.08 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.20 Pain Relevance 0.72
The demonstration of the bidirectional cross-tolerance between the peripheral antinociceptive effects of DAMGO and CPA supports the hypothesis that both these agents produced antinociception by acting on the same cell, presumably the primary afferent nociceptor, and that the development of tolerance involves changes downstream to activation of mu-opioid and A1-adenosine receptors.
Positive_regulation (activation) of A1-adenosine in nociceptor associated with antinociception, adenocard, nociceptor, tolerance, opioid and antinociceptive
18) Confidence 0.07 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613740 Disease Relevance 0.35 Pain Relevance 2.16
KATP-channel activity also appears to be increased by extracellular adenosine via adenosine A1 receptor stimulation (Heurteaux et al 1995).
Positive_regulation (increased) of adenosine A1 receptor associated with adenocard
19) Confidence 0.06 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.18 Pain Relevance 0.46
Augmenting (lowering) GABA release can be provided by activation of presynaptic D1 and M3 receptors (mu, 5-HT1, and adenosine A1) receptors.
Positive_regulation (activation) of adenosine A1 associated with adenocard and gaba
20) Confidence 0.01 Published 2003 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 14598554 Disease Relevance 0 Pain Relevance 0.58

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